Document Detail


Size-dependent lipid content in human milk fat globules.
MedLine Citation:
PMID:  18656925     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human milk fat globules (HMFGs) are considered to constitute a triglyceride-rich source of fat and energy. However, milk contains lipid particles at different sizes ranging from tens of micrometers to less than 1 microm. In particular, the physical, chemical, and biological properties of submicron sized particles are poorly described. Individual HMFGs were analyzed using laser trapping confocal Raman spectroscopy, and their chemical signature was obtained and compared to 1, 5, and 10 microm globules. Significant differences in both lipid composition and relative lipid content were found between the classes of particles with different diameters. A strong Raman peak at 1742 cm(-1) corresponding to the triacylglycerol core was detected in the 5 and 10 microm diameter globules, whereas in the smaller HMFGs no detectable peak was found. In addition, the submicron particles produced Raman signals consistent with large quantities of unsaturated fatty acids. Moreover, cis and trans isomers of unsaturated fatty acids were found to be unequally distributed between large and small milk fat globules. Interestingly, trans unsaturated fatty acids were found only in 1 and 5 microm globules although more prominent in the 5 microm diameter range. This is the first evidence for size related differential lipid composition of various diameter classes of HMFGs. The results suggest that the milk fat globule size distribution determines milk lipid composition. In addition, large portions of the HMFGs are secreted into milk conspicuously not for fat delivery. Thus, small HMFGs may offer novel metabolic and nutritional functions.
Authors:
Nurit Argov; Sebastian Wachsmann-Hogiu; Samara L Freeman; Thomas Huser; Carlito B Lebrilla; J Bruce German
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-07-26
Journal Detail:
Title:  Journal of agricultural and food chemistry     Volume:  56     ISSN:  1520-5118     ISO Abbreviation:  J. Agric. Food Chem.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-08-21     Completed Date:  2008-10-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374755     Medline TA:  J Agric Food Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7446-50     Citation Subset:  IM    
Affiliation:
Department of Food Science and Technology, University of California Davis, 1 Shields Avenue, Davis, California 95616, USA. nargov@ucdavis.edu
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MeSH Terms
Descriptor/Qualifier:
Glycolipids / chemistry*
Glycoproteins / chemistry*
Humans
Lipids / analysis*,  chemistry*
Particle Size
Spectrum Analysis, Raman
Chemical
Reg. No./Substance:
0/Glycolipids; 0/Glycoproteins; 0/Lipids; 0/milk fat globule

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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