| Size of the corpus callosum in cerebral palsy. | |
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MedLine Citation:
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PMID: 8704295 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It has been suggested that the size of the corpus callosum may have diagnostic significance in cerebral palsy, although this relationship is incompletely defined. Ninety-one patients with cerebral palsy had been studied by magnetic resonance imaging in the 5-year period from 1990 to 1994. Fifty-seven of these 91 patients had a technically appropriate midsagittal magnetic resonance image for quantitative morphometric analysis. The ratio of the area of the corpus callosum to the area of the supratentorial brain was compared to published age- and gender-specific norms. Imaging findings were correlated with clinical history and cause of cerebral palsy. The corpus callosum was of normal size in 43 patients and more than 2 standard deviations below the mean in 14 patients. The causes for cerebral palsy included hypoxic ischemic encephalopathy (32), cerebral dysgenesis (8), and porencephalic strokes (6); the etiology could not be established in 11 patients. The size of the corpus callosum was highly correlated with the cause of cerebral palsy, such that all patients with cerebral dysgenesis had hypoplasia of the corpus callosum (one-sided z test, p < 0.0001). Conversely, the callosum was of normal size in 32 of 38 patients with hypoxic ischemic encephalopathy and porencephalic strokes. The presence of a hypoplastic corpus callosum is highly associated with cerebral dysgenesis as a cause for cerebral palsy. |
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Authors:
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R D Sheth; G B Schaefer; G M Keller; G R Hobbs; O Ortiz; J B Bodensteiner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of neuroimaging : official journal of the American Society of Neuroimaging Volume: 6 ISSN: 1051-2284 ISO Abbreviation: J Neuroimaging Publication Date: 1996 Jul |
Date Detail:
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Created Date: 1996-09-10 Completed Date: 1996-09-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9102705 Medline TA: J Neuroimaging Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 180-3 Citation Subset: IM |
Affiliation:
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Department of Neurology, West Virginia University Morgantown 26506-9180, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Age Factors Aged Aged, 80 and over Brain / abnormalities Brain Ischemia / complications Cerebellum / pathology Cerebral Palsy / diagnosis, etiology, pathology* Cerebrovascular Disorders / complications Child Child, Preschool Corpus Callosum / abnormalities, pathology* Female Humans Hypoxia, Brain / complications Magnetic Resonance Imaging* Male Middle Aged Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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MCJ-549170//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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