| Size at birth and cord blood levels of insulin, insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-1 (IGFBP-1), IGFBP-3, and the soluble IGF-II/mannose-6-phosphate receptor in term human infants. The ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood. | |
| | |
MedLine Citation:
|
PMID: 11095465 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Experimental rodent studies demonstrate that insulin-like growth factor II (IGF-II) promotes fetal growth, whereas the nonsignaling IGF-II receptor (IGF2R) is inhibitory; in humans their influence is as yet unclear. A soluble, circulating form of IGF2R inhibits IGF-II mediated DNA synthesis and may therefore restrain fetal growth. We measured cord blood levels of IGF-II, soluble IGF2R, insulin, IGF-I, IGF-binding protein-1 (IGFBP-1), and IGFBP-3 and examined their relationships to weight, length, head circumference, ponderal index, and placental weight at birth in 199 normal term singletons. IGF-II levels correlated with levels of IGF-I (r = 0.29; P < 0.0005), IGFBP-3 (r = 0.45; P < 0.0005), and soluble IGF2R (r = 0.20; P < 0.005). Insulin and IGF-I were positively related to all parameters of size at birth. IGF-II was weakly related to ponderal index (r = 0.18; P < 0.05) and placental weight (r = 0.18; P < 0.05), and the molar ratio of IGF-II to IGF2R was also related to birth weight (r = 0.15; P < 0.05). Correlations between the IGFs and size at birth were stronger in nonprimiparous pregnancies; in these, IGF-I (r = 0.52; P < 0.0005), IGFBP-3 (r = 0.41; P < 0.0005), and the IGF-II to IGF2R ratio (r = 0.40; P < 0.0005) were most closely related to placental weight, together accounting for 39% of its variance. We demonstrate for the first time relationships between circulating IGF-II and soluble IGF2R levels and size at birth, supporting their putative opposing roles in human fetal growth. |
| | |
Authors:
|
K Ong; J Kratzsch; W Kiess; M Costello; C Scott; D Dunger |
Related Documents
:
|
12847535 - Prediction of extrauterine growth retardation (eugr) in vvlbw infants. 10462155 - A longitudinal study of the physical growth of japanese infants. 18185085 - Nutrient supplies for optimal health in preterm infants. 20217065 - Sonographic assessment of renal size and growth in premature infants. 6976675 - Placental transfer of maternal anti-rabbit igg causing falsely elevated tsh levels in n... 9298635 - Preexposure effects on infant learning and memory. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Journal of clinical endocrinology and metabolism Volume: 85 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2000 Nov |
Date Detail:
|
Created Date: 2000-11-29 Completed Date: 2000-12-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 4266-9 Citation Subset: AIM; IM |
Affiliation:
|
Department of Paediatrics, University of Cambridge, Addenbrookes Hospital, United Kingdom. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Body Constitution* Cohort Studies Female Fetal Blood / chemistry* Human Growth Hormone / blood Humans Infant, Newborn* Insulin / blood* Insulin-Like Growth Factor Binding Protein 1 / blood* Insulin-Like Growth Factor Binding Protein 3 / blood* Insulin-Like Growth Factor I / analysis* Insulin-Like Growth Factor II / analysis* Male Placenta Pregnancy Receptor, IGF Type 2 / blood* Reference Values Regression Analysis |
| Chemical | |
Reg. No./Substance:
|
0/Insulin-Like Growth Factor Binding Protein 1; 0/Insulin-Like Growth Factor Binding Protein 3; 0/Receptor, IGF Type 2; 11061-68-0/Insulin; 12629-01-5/Human Growth Hormone; 67763-96-6/Insulin-Like Growth Factor I; 67763-97-7/Insulin-Like Growth Factor II |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Serum levels of insulin-like growth factor I (IGF-I), IGF-II, IGF-binding protein-3, and prostate-sp...
Next Document: High prevalence of antineutrophil cytoplasmic antibody positivity in childhood onset Graves' disease...