Document Detail

Size at birth and adult fat mass in twin sheep are determined in early gestation.
MedLine Citation:
PMID:  22183720     Owner:  NLM     Status:  MEDLINE    
Size at birth is related to adult health outcomes. Twins are born smaller than singletons; this has been assumed to be secondary to limited nutrient supply in late gestation.We hypothesised that growth trajectory in twins, and the adult consequences of being conceived a twin, are determined in early gestation. Twin pregnancies in sheep were randomised to reduction of one twin on day 42 of a 148 day pregnancy by intra-thoracic KCl (Reductions, n =46) or a sham procedure (Twins, n =22). Singleton-bearing ewes also underwent a sham procedure (n =27). Ewes lambed spontaneously. Linear measures of size at birth were similar in Twins and Reductions, and significantly less than in Singletons. Birthweight was lower in Twins and Reductions than in Singletons, and less in Twins than in Reductions (means (SEM): Singletons, liveborn n =23: 6.59 (0.17) kg; Twins, liveborn n =36: 5.23 (0.16) kg; Reductions, liveborn n =27: 5.76 (0.15) kg; all comparisons P <0.05). Reductions grew most rapidly between birth and weaning (Singletons, 20.0 (0.4) g kg⁻¹ day⁻¹; Twins, 20.0 (0.3) g kg⁻¹ day⁻¹; Reductions, 21.0 (0.3) g kg⁻¹ day⁻¹, P <0.05) and were of similar weight as Singletons by weaning; Twins remained smaller by weaning but grew most rapidly thereafter (Singletons, 1.6 (0.1) g kg⁻¹ day⁻¹; Twins, 2.1 (0.1) g kg⁻¹ day⁻¹; Reductions, 1.6 (0.1) g kg⁻¹ day⁻¹, P <0.01), so that all groups had similar weight at 2 years. However, Twins and Reductions had greater percentage fat mass than Singletons at 2 years (Singletons, 11.1 (1.1)%; Twins, 14.8 (1.2)%; Reductions, 15.5 (1.1)%, P <0.05). Thus, in twins, fetal growth trajectory, linear size at birth and adult fat mass are largely determined in early gestation. If this is also true in humans, there are important implications for interventions aimed at optimising fetal growth and pregnancy outcome.
S N Hancock; M H Oliver; C McLean; A L Jaquiery; F H Bloomfield
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-12-19
Journal Detail:
Title:  The Journal of physiology     Volume:  590     ISSN:  1469-7793     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-08     Completed Date:  2012-07-03     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1273-85     Citation Subset:  IM    
Liggins Institute, University of Auckland and National Research Centre for Growth and Development, Auckland, New Zealand.
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MeSH Terms
3-Hydroxybutyric Acid / blood
Adipose Tissue / anatomy & histology*
Birth Weight*
Blood Glucose / analysis
Estradiol / blood
Fatty Acids, Nonesterified / blood
Gestational Age*
Hydrocortisone / blood
Insulin / blood
Insulin-Like Growth Factor I / metabolism
Litter Size*
Pregnancy, Animal*
Progesterone / blood
Sheep / anatomy & histology*,  physiology
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 0/Insulin; 300-85-6/3-Hydroxybutyric Acid; 50-23-7/Hydrocortisone; 50-28-2/Estradiol; 57-83-0/Progesterone; 67763-96-6/Insulin-Like Growth Factor I
Comment In:
J Physiol. 2012 Mar 1;590(Pt 5):1021-2   [PMID:  22399820 ]

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