| Size at Birth, Weight Gain in Infancy and Childhood, and Adult Diabetes Risk in Five Low- or Middle-Income Country Birth Cohorts. | |
| | |
MedLine Citation:
|
PMID: 22100968 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVEWe examined associations of birth weight and weight gain in infancy and early childhood with type 2 diabetes (DM) risk in five cohorts from low- and middle-income countries.RESEARCH DESIGN AND METHODSParticipants were 6,511 young adults from Brazil, Guatemala, India, the Philippines, and South Africa. Exposures were weight at birth, at 24 and 48 months, and adult weight, and conditional weight gain (CWG, deviation from expected weight gain) between these ages. Outcomes were adult fasting glucose, impaired fasting glucose or DM (IFG/DM), and insulin resistance homeostasis model assessment (IR-HOMA, three cohorts).RESULTSBirth weight was inversely associated with adult glucose and risk of IFG/DM (odds ratio 0.91[95% CI 0.84-0.99] per SD). Weight at 24 and 48 months, and CWG 0-24 and 24-48 months, were unrelated to glucose and IFG/DM; however, CWG 48 months-adult was positively related to IFG/DM (1.32 [1.22-1.43] per SD). After adjusting for adult waist circumference, birth weight, weight at 24 and 48 months, and CWG 0-24 months were inversely associated with glucose and IFG/DM. Birth weight was unrelated to IR-HOMA, whereas greater CWG at 0-24 and 24-48 months, and 48 months-adults predicted higher IR-HOMA (all P < 0.001). After adjusting for adult waist circumference, birth weight was inversely related to IR-HOMA.CONCLUSIONSLower birth weight and accelerated weight gain after 48 months are risk factors for adult glucose intolerance. Accelerated weight gain between 0 and 24 months did not predict glucose intolerance but did predict higher insulin resistance. |
| | |
Authors:
|
Shane A Norris; Clive Osmond; Denise Gigante; Christopher W Kuzawa; Lakshmy Ramakrishnan; Nanette R Lee; Manual Ramirez-Zea; Linda M Richter; Aryeh D Stein; Nikhil Tandon; Caroline H D Fall; |
Related Documents
:
|
7875048 - No association between anti-bovine serum albumin antibodies and islet cell reactive ant... 9507918 - Antibodies to pancreatic islet cell antigens in diabetes seen in southern india with pa... 9475358 - Hla-drb1 alleles contribute to determining the prognosis of japanese diabetes mellitus ... 17583798 - Effect of oral insulin on insulin autoantibody levels in the diabetes prevention trial ... 9284898 - L-arginine but not d-arginine stimulates insulin-mediated glucose uptake. 3543638 - Cerebral edema complicating nonketotic hyperosmolar coma. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-18 |
Journal Detail:
|
Title: Diabetes care Volume: - ISSN: 1935-5548 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7805975 Medline TA: Diabetes Care Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Medical Research Council/Wits Developmental Pathways for Health Research Unit, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Processed and Unprocessed Red Meat Consumption and Incident Type 2 Diabetes Among French Women.
Next Document: Detection of inadequate effort on neuropsychological testing: a meta-analytic update and extension.