| Sixteen years and counting: an update on leptin in energy balance. | |
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MedLine Citation:
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PMID: 21633176 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cloned in 1994, the ob gene encodes the protein hormone leptin, which is produced and secreted by white adipose tissue. Since its discovery, leptin has been found to have profound effects on behavior, metabolic rate, endocrine axes, and glucose fluxes. Leptin deficiency in mice and humans causes morbid obesity, diabetes, and various neuroendocrine anomalies, and replacement leads to decreased food intake, normalized glucose homeostasis, and increased energy expenditure. Here, we provide an update on the most current understanding of leptin-sensitive neural pathways in terms of both anatomical organization and physiological roles. |
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Authors:
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Laurent Gautron; Joel K Elmquist |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2011-06-01 |
Journal Detail:
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Title: The Journal of clinical investigation Volume: 121 ISSN: 1558-8238 ISO Abbreviation: J. Clin. Invest. Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-06-02 Completed Date: 2011-08-17 Revised Date: 2012-02-07 |
Medline Journal Info:
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Nlm Unique ID: 7802877 Medline TA: J Clin Invest Country: United States |
Other Details:
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Languages: eng Pagination: 2087-93 Citation Subset: AIM; IM |
Affiliation:
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Department of Internal Medicine, Division of Hypothalamic Research, The University of Texas Southwestern Medical Center, Dallas, Texas, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adaptation, Physiological Adipose Tissue, White / secretion Animals Body Weight / physiology Brain / physiology Disease Models, Animal Energy Metabolism / physiology* Feeding Behavior / physiology Glucose / metabolism Humans Hypothalamus / physiology Leptin / deficiency, genetics, physiology* Mice Mice, Obese Models, Biological Overnutrition / physiopathology Pro-Opiomelanocortin / physiology Receptor, Melanocortin, Type 4 / physiology Receptors, Leptin / deficiency, genetics, physiology* Starvation / physiopathology Sympathetic Nervous System / physiology |
| Chemical | |
Reg. No./Substance:
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0/Leptin; 0/Receptor, Melanocortin, Type 4; 0/Receptors, Leptin; 50-99-7/Glucose; 66796-54-1/Pro-Opiomelanocortin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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