Document Detail

Sixteen weeks of exercise reduces C-reactive protein levels in young women.
MedLine Citation:
PMID:  21085036     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Regular exercise has been shown to protect against breast cancer risk, and one possible mechanism is through a reduction in inflammation. The purpose of this study was to examine the effects of 16 wk of aerobic exercise training on adipokines and inflammatory markers in healthy young women.
METHODS: Participants were 319 sedentary women aged 18-30 yr, with body mass index of 18-40 kg · m, randomized to an exercise intervention or no exercise for approximately 16 wk. Adiponectin, leptin, C-reactive protein (CRP), and amyloid A (AA) were measured at baseline and after 16 wk. Adiponectin was measured by enzyme-linked immunosorbent assay, and AA, CRP, and leptin were measured by multiplex bead array assays.
RESULTS: Exercise significantly decreased CRP levels in the exercise group compared with the control group (-1.41 mg · L in exercisers vs -0.005 mg · L in controls, P = 0.040), and this effect was largely driven by changes in CRP that occurred in the obese exercisers. There was no effect of exercise on levels of SAA, adiponectin, or leptin. There was also no effect of exercise on stress and depression scores. Neither change in percent body fat nor change in fitness influenced the effects of exercise on these inflammatory markers.
CONCLUSIONS: This study demonstrated that a 16-wk aerobic exercise program significantly decreased levels of CRP in young women, especially in those who were obese. There was no evidence that this effect was mediated by changes in perceived stress, percent body fat, or fitness. These findings suggest that adopting an exercise routine early in life may decrease future risk of breast cancer and other chronic diseases in obese women.
Andrea Y Arikawa; William Thomas; Kathryn H Schmitz; Mindy S Kurzer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  43     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-17     Completed Date:  2011-09-27     Revised Date:  2014-06-06    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1002-9     Citation Subset:  IM; S    
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MeSH Terms
Adiponectin / blood
Body Fat Distribution
C-Reactive Protein / analysis*
Leptin / blood
Obesity / blood
Serum Amyloid A Protein / analysis
Young Adult
Grant Support
M01-RR00400/RR/NCRR NIH HHS; R01 CA131333/CA/NCI NIH HHS; U54 CA116849/CA/NCI NIH HHS; U54 CA116849/CA/NCI NIH HHS
Reg. No./Substance:
0/Adiponectin; 0/Leptin; 0/Serum Amyloid A Protein; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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