Document Detail

Six years of experience with the use of room air for the resuscitation of asphyxiated newly born term infants.
MedLine Citation:
PMID:  11275663     Owner:  NLM     Status:  MEDLINE    
In the last 6 years, 830 asphyxiated newly born term infants have been resuscitated with room air (RAR; n = 304) or 100% oxygen (OxR; n = 526) in our hospital. We have studied the time to onset of a regular respiratory pattern, morbidity and mortality, blood gases, reduced glutathione (GSH) and oxidised glutathione (GSSG) and antioxidant enzymes in these infants. No significant differences in the effectiveness of either gas sources or in the final outcome have been found. The RAR group required a shorter time of positive pressure ventilation to attain a spontaneous pattern of respiration. The OxR group showed hyperoxaemia during resuscitation, which was positively correlated with increased GSSG concentrations. Significant oxidative stress was found in the OxR group at 28 days of postnatal life when compared with normal control infants and the RAR group. Oxygen concentrations used during the resuscitation of newly born infants should be strictly monitored.
M Vento; M Asensi; J Sastre; F García-Sala; J Viña
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Biology of the neonate     Volume:  79     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2001  
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-07-12     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  261-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Departamento de Pediatría y Neonatología, Hospital Virgen del Consuelo, Valencia, España.
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MeSH Terms
Asphyxia Neonatorum / blood,  mortality,  therapy*
Carbon Dioxide / blood
Catalase / blood
Glutathione / blood
Glutathione Peroxidase / blood
Infant, Newborn
Oxygen / administration & dosage*,  adverse effects,  blood
Resuscitation / methods*
Superoxide Dismutase / blood
Reg. No./Substance:
124-38-9/Carbon Dioxide; 70-18-8/Glutathione; 7782-44-7/Oxygen; EC; EC Peroxidase; EC Dismutase

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