Document Detail

Six-year supplementation with alpha-tocopherol and beta-carotene and age-related maculopathy.
MedLine Citation:
PMID:  9591958     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Animal research and observational studies in man suggest a protective effect of antioxidant vitamins in the development of age-related maculopathy (ARM). METHODS: The ATBC study, a population-based, controlled clinical trial of alpha-tocopherol and beta carotene to prevent lung cancer, took place in Finland between 1984 and 1993. Over 29,000 smoking males aged 50 to 69 years were randomly assigned to alpha-tocopherol (AT; 50 mg/day), beta-carotene (BC; 20 mg/day), both of these, or placebo. We performed an end-of-trial ophthalmological examination on a random sample of 941 participants aged 65 years or more from two of the fourteen study areas, to discover if the five to eight-year intervention with alpha-tocopherol and/or beta-carotene had been associated with a difference in ARM prevalence. Age-related maculopathy was assessed using colour photographs of the macula. RESULTS: Altogether, 269 cases of ARM were found; there were more cases in the AT group (32%; 75/237), BC group (29%; 68/234), and combined antioxidant group (28%; 73/257) than in the placebo group (25%; 53/213). However, neither substance was significantly associated with the risk of ARM in a logistic regression analysis controlling for possible risk factors. CONCLUSIONS: No beneficial effect of long-term supplementation with alpha-tocopherol or beta-carotene on the occurrence of ARM was detected among smoking males.
J M Teikari; L Laatikainen; J Virtamo; J Haukka; M Rautalahti; K Liesto; D Albanes; P Taylor; O P Heinonen
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  76     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  1998 Apr 
Date Detail:
Created Date:  1998-06-19     Completed Date:  1998-06-19     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  224-9     Citation Subset:  IM    
Department of Public Health, University of Helsinki, Finland.
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MeSH Terms
Aging / physiology*
Antioxidants / therapeutic use*
Double-Blind Method
Lung Neoplasms / prevention & control
Macula Lutea*
Retinal Diseases / drug therapy*,  epidemiology
Vitamin E / therapeutic use*
beta Carotene / therapeutic use*
Grant Support
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 7235-40-7/beta Carotene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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