Document Detail

Six-year follow-up of a cohort of 203 patients with diabetes after screening for silent myocardial ischaemia.
MedLine Citation:
PMID:  17054593     Owner:  NLM     Status:  MEDLINE    
AIMS: To determine the prognosis of patients with Type 1 or Type 2 diabetes, 6 years after screening for silent myocardial ischaemia (SMI). METHODS: Two hundred and three asymptomatic patients with diabetes underwent systematic SMI screening. From the results of this screening, they were allocated to one of three groups: patients (n = 171) with negative screening; patients (n = 32) with positive screening; and patients (n = 21) with positive screening and coronary stenosis. Six years after the initial assessment, all patients were re-assessed. All events [death, cardiac death, non-fatal major cardiac events (NFMCEs)--acute myocardial infarction, ventricular rhythm disorders, heart failure, unstable angina] were recorded. RESULTS: Fifteen patients were lost to follow-up. Patients (n = 20) with positive SMI screening and coronary stenosis had a higher risk of NFMCEs (35% vs. 7%, P < 0.001), and a higher mortality rate (35% vs. 15%, P < 0.05) compared with patients (n = 157) with negative screening. SMI-positive patients (n = 31) had a higher NFMCE rate compared with negative SMI screening patients, although overall mortality rate was no different. Cancer was the leading cause of death (36.4%). In multivariate analysis, major cardiac events (cardiac death and NFMCE) were related to baseline age, body mass index and coronary stenosis (P < 0.01). CONCLUSIONS: Patients with diabetes and SMI have a very poor prognosis as assessed by cardiac events or death, especially in the presence of coronary stenosis.
S Sejil; B Janand-Delenne; J-F Avierinos; G Habib; N Labastie; D Raccah; P Vague; V Lassmann-Vague
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Diabetic medicine : a journal of the British Diabetic Association     Volume:  23     ISSN:  0742-3071     ISO Abbreviation:  Diabet. Med.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-23     Completed Date:  2007-05-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8500858     Medline TA:  Diabet Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  1186-91     Citation Subset:  IM    
Endocrinology-Nutrition-Metabolic Disease Department, Timone University Hospital Centre, Marseille, France.
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MeSH Terms
Cohort Studies
Diabetes Mellitus, Type 1 / diagnosis*
Diabetes Mellitus, Type 2 / diagnosis*
Diabetic Angiopathies / diagnosis*
Follow-Up Studies
Middle Aged
Myocardial Ischemia / diagnosis*

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