Document Detail


Six-year follow-up of botulinum toxin A intradetrusorial injections in patients with refractory neurogenic detrusor overactivity: clinical and urodynamic results.
MedLine Citation:
PMID:  18814955     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Most reports in the literature on botulinum toxin A (BoNTA) therapy for neurogenic detrusor overactivity (NDO) are based on the results of a single injection. Because most patients may require retreatment, the efficacy and safety of multiple injections must be addressed clearly. OBJECTIVE: To investigate the effectiveness and safety of BoNTA intradetrusorial injections in a group of spinal cord-injured (SCI) patients with refractory detrusor overactivity (DO). DESIGN, SETTING, AND PARTICIPANTS: Seventeen SCI patients were prospectively included in the study and followed up to 6 yr. INTERVENTION: All patients received repeat intradetrusorial injections of BoNTA 300 units (Botox, Allergan, Irvine, CA) under cystoscopic control on an inpatient basis. MEASUREMENTS: The preliminary assessment included voiding diary, urodynamics, kidney and bladder ultrasound, and cystourethrography. Patients also completed a standardised quality-of-life (QoL) questionnaire. Clinical evaluation, urodynamics, urinary tract imaging, and QoL assessment were repeated every year throughout the follow-up. RESULTS AND LIMITATIONS: Before treatment, all patients complained of urinary incontinence and had DO. Bilateral and monolateral renal pelvis dilatation were detected in six and five patients, respectively, and a monolateral and third-grade vesicoureteral reflux was observed in three. At 6-yr follow-up, a significant decrease in the frequency of daily incontinence episodes (p<0.01), a significant increase in first uninhibited detrusor contraction and in maximum bladder capacity (p<0.001 for both), and a significant decrease in maximum pressure of these contractions (p<0.01) were observed. Fifteen patients (88.2%) were completely continent. Renal pelvis dilatation and vesicoureteral reflux resolved in all cases, and the QoL index significantly increased. Limitations of the study are related to the small number of included patients. CONCLUSIONS: In SCI patients with refractory NDO who do not want or are unfit for invasive reconstructive surgery, BoNTA intravesical treatment represents a valid alternative to control DO and urinary incontinence and to preserve upper urinary tract function over a long-term follow-up.
Authors:
Antonella Giannantoni; Ettore Mearini; Michele Del Zingaro; Massimo Porena
Related Documents :
9449585 - Prophylaxis and treatment of bladder dysfunction after wertheim-meigs operation: the po...
18595225 - Results of application of orthotopic urine diversion according to studer.
15828955 - Intussusception of the bladder neck does not promote early restoration to urinary conti...
10792155 - Bacillus calmette-guérin instillation treatment for carcinoma in situ of the upper urin...
15042375 - Visual outcome of patients with macular edema after pars plana vitrectomy and indocyani...
15001915 - A 25-year experience with open primary transthoracic repair of paraesophageal hiatal he...
Publication Detail:
Type:  Journal Article     Date:  2008-09-02
Journal Detail:
Title:  European urology     Volume:  55     ISSN:  1873-7560     ISO Abbreviation:  Eur. Urol.     Publication Date:  2009 Mar 
Date Detail:
Created Date:  2009-07-29     Completed Date:  2009-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7512719     Medline TA:  Eur Urol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  705-11     Citation Subset:  IM    
Affiliation:
Department of Urology and Andrology, University of Perugia, Ospedale S. Maria della Misericordia, Perugia, Italy. agianton@libero.it
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Botulinum Toxin Type A / administration & dosage*
Female
Follow-Up Studies
Humans
Injections, Intramuscular
Male
Neuromuscular Agents / administration & dosage*
Prospective Studies
Spinal Cord Injuries / complications
Time Factors
Urinary Bladder, Neurogenic / drug therapy*,  etiology,  physiopathology
Urinary Bladder, Overactive / drug therapy*,  etiology,  physiopathology
Urodynamics*
Chemical
Reg. No./Substance:
0/Botulinum Toxin Type A; 0/Neuromuscular Agents
Comments/Corrections
Comment In:
Eur Urol. 2009 Mar;55(3):712   [PMID:  18814958 ]
Eur Urol. 2009 Mar;55(3):560-2   [PMID:  18805630 ]
Eur Urol. 2009 Mar;55(3):711-2   [PMID:  18814956 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Sustainability, substance-flow management, and time, Part II: Temporal impact assessment (TIA) for s...
Next Document:  Identification of novel p53 target genes by cDNA AFLP in glioblastoma cells.