| Six-year follow-up after Helicobacter pylori eradication in peptic ulcer disease. | |
| | |
MedLine Citation:
|
PMID: 11440407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: The longterm outlook after Helicobacter pylori (H. pylori) eradication in peptic ulcer disease is unclear. AIM: This study documents H. pylori recurrence, dyspeptic symptoms and anti-secretory therapy in peptic ulcer patients six years or more after H. pylori eradication. METHODS: Peptic ulcer patients with H. pylori eradication between 1990 and 1992 were included. Infection recurrence was diagnosed by 13-carbon urea breath test (UBT). Dyspeptic symptoms and anti-secretory therapy use were assessed by questionnaire. RESULTS: Sixty-one patients completed the study protocol. Mean follow-up after eradication was 6.1 years (range 4.8-8.3). Four patients had a positive UBT. H. pylori recurrence rate was 6.6% or 0.02% per patient per year. Forty-two patients (69%) had dyspeptic symptoms. Heartburn and belching were more common than pain (p<0.001). All four patients with H. pylori recurrence had symptoms compared with 38 of 57 H. pylori-negative patients (p>0.05). Ten of 61 patients (16.4%) were taking anti-secretory therapy and their dyspepsia scores were higher. CONCLUSIONS: Despite a low H. pylori recurrence rate, longterm dyspeptic symptoms were common in peptic ulcer patients after H. pylori eradication. The symptoms are mainly reflux in type and require anti-secretory therapy in only a minority of patients. |
| | |
Authors:
|
H J O'Connor; C Stewart; R Walsh; C N McGee; B Flynn |
Related Documents
:
|
1455197 - Triple therapy of helicobacter pylori infection in peptic ulcer. a 12-month follow-up s... 11336157 - Functional dyspepsia is associated with caga-positive helicobacter pylori strains. 23527767 - Missed therapy time during inpatient rehabilitation for spinal cord injury. 15975537 - Clinical usefulness of serum pepsinogens i and ii, gastrin-17 and anti-helicobacterpylo... 17373977 - Nail changes in connective tissue diseases: do nail changes provide clues for the diagn... 10690387 - Relapses of childhood anaplastic large-cell lymphoma: treatment results in a series of ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Irish journal of medical science Volume: 170 ISSN: 0021-1265 ISO Abbreviation: Ir J Med Sci Publication Date: 2001 Jan-Mar |
Date Detail:
|
Created Date: 2001-07-06 Completed Date: 2001-08-02 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7806864 Medline TA: Ir J Med Sci Country: Ireland |
Other Details:
|
Languages: eng Pagination: 24-7 Citation Subset: IM |
Affiliation:
|
Department of Medicine, General Hospital, Tullamore, Co Offaly, Ireland. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anti-Ulcer Agents
/
therapeutic use Drug Therapy, Combination Female Follow-Up Studies Helicobacter Infections / diagnosis, drug therapy, epidemiology* Helicobacter pylori* Humans Male Middle Aged Peptic Ulcer / microbiology* Recurrence Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Ulcer Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Where do patients with cancer die in Belfast?
Next Document: Clinical outcome after acquisition of Burkholderia cepacia in patients with cystic fibrosis.