Document Detail

Six-year follow-up after Helicobacter pylori eradication in peptic ulcer disease.
MedLine Citation:
PMID:  11440407     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The longterm outlook after Helicobacter pylori (H. pylori) eradication in peptic ulcer disease is unclear. AIM: This study documents H. pylori recurrence, dyspeptic symptoms and anti-secretory therapy in peptic ulcer patients six years or more after H. pylori eradication. METHODS: Peptic ulcer patients with H. pylori eradication between 1990 and 1992 were included. Infection recurrence was diagnosed by 13-carbon urea breath test (UBT). Dyspeptic symptoms and anti-secretory therapy use were assessed by questionnaire. RESULTS: Sixty-one patients completed the study protocol. Mean follow-up after eradication was 6.1 years (range 4.8-8.3). Four patients had a positive UBT. H. pylori recurrence rate was 6.6% or 0.02% per patient per year. Forty-two patients (69%) had dyspeptic symptoms. Heartburn and belching were more common than pain (p<0.001). All four patients with H. pylori recurrence had symptoms compared with 38 of 57 H. pylori-negative patients (p>0.05). Ten of 61 patients (16.4%) were taking anti-secretory therapy and their dyspepsia scores were higher. CONCLUSIONS: Despite a low H. pylori recurrence rate, longterm dyspeptic symptoms were common in peptic ulcer patients after H. pylori eradication. The symptoms are mainly reflux in type and require anti-secretory therapy in only a minority of patients.
H J O'Connor; C Stewart; R Walsh; C N McGee; B Flynn
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Irish journal of medical science     Volume:  170     ISSN:  0021-1265     ISO Abbreviation:  Ir J Med Sci     Publication Date:    2001 Jan-Mar
Date Detail:
Created Date:  2001-07-06     Completed Date:  2001-08-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  24-7     Citation Subset:  IM    
Department of Medicine, General Hospital, Tullamore, Co Offaly, Ireland.
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MeSH Terms
Anti-Ulcer Agents / therapeutic use
Drug Therapy, Combination
Follow-Up Studies
Helicobacter Infections / diagnosis,  drug therapy,  epidemiology*
Helicobacter pylori*
Middle Aged
Peptic Ulcer / microbiology*
Time Factors
Reg. No./Substance:
0/Anti-Ulcer Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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