| Six-week supplementation with Chlorella has favorable impact on antioxidant status in Korean male smokers. | |
| | |
MedLine Citation:
|
PMID: 19660910 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Chlorella vulgaris is a popular food supplement in Asia and is currently marketed as a nutritional supplement. However, available scientific studies do not support its effectiveness for preventing or treating any disease in humans. Because Chlorella contains numerous nutrients, including antioxidants, it is thought to exert antioxidative functions by scavenging free radicals created by various environmental factors such as smoking. The purpose of this study was to investigate whether 6 wk of Chlorella supplementation to smokers is protective against oxidative damage in a randomized, double-blinded, placebo-controlled trial. METHODS: Fifty-two smokers, aged 20-65 y, were given 6.3g of Chlorella or placebo every day for 6 wk. Blood samples were drawn at the beginning and after the supplementation. Plasma antioxidant vitamin levels and lipid peroxidation levels were measured. As a marker of oxidative stress, lymphocyte DNA damage was measured. RESULTS: Chlorella supplementation increased plasma vitamin C (44.4%), alpha-tocopherol (15.7%), and erythrocyte catalase and superoxide dismutase activities. Although 6 wk of Chlorella supplementation resulted in a significant decrease in lymphocyte DNA damage, as measured by comet assay, placebo supplementation also decreased the measured amount of lymphocyte DNA damage. CONCLUSION: Chlorella supplementation resulted in the conservation of plasma antioxidant nutrient status and improvement in erythrocyte antioxidant enzyme activities in subjects. Therefore, our results are supportive of an antioxidant role for Chlorella and indicate that Chlorella is an important whole-food supplement that should be included as a key component of a healthy diet. |
| | |
Authors:
|
Sun Hee Lee; Hae Jin Kang; Hye-Jin Lee; Myung-Hee Kang; Yoo Kyoung Park |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2009-08-05 |
Journal Detail:
|
Title: Nutrition (Burbank, Los Angeles County, Calif.) Volume: 26 ISSN: 1873-1244 ISO Abbreviation: Nutrition Publication Date: 2010 Feb |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-05-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8802712 Medline TA: Nutrition Country: United States |
Other Details:
|
Languages: eng Pagination: 175-83 Citation Subset: IM |
Copyright Information:
|
2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Medical Nutrition, Graduate School of East-West Medical Science, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Antioxidants / metabolism*, pharmacology* Ascorbic Acid / blood Catalase / blood Chlorella* DNA Damage / drug effects Dietary Supplements Double-Blind Method Erythrocytes / drug effects Humans Korea Lymphocytes / drug effects Male Middle Aged Oxidative Stress / drug effects Placebo Effect Plant Preparations / pharmacology* Smoking / metabolism* Superoxide Dismutase / metabolism alpha-Tocopherol / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Antioxidants; 0/Plant Preparations; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol; EC 1.11.1.6/Catalase; EC 1.15.1.1/Superoxide Dismutase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pretreatment with arginine preserves intestinal barrier integrity and reduces bacterial translocatio...
Next Document: An assessment of the effectiveness of growth monitoring and promotion practices in the Lusaka distri...