| Situs inversus, bronchiectasis, and sinusitis and its relation to immotile cilia: history of the diseases and their discoverers-Manes Kartagener and Bjorn Afzelius. | |
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MedLine Citation:
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PMID: 14551758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The relationship of Kartagener's syndrome to immobile cilia syndrome is a fascinating merging of clinical observations and basic science in Zurich, Stockholm, and Toronto. In 1933, Manes Kartagener, a Zurich pulmonary physician, reported four patients with the triad of sinusitis, bronchiectasis, and situs inversus. In the following decades, he reviewed reports of hundreds of cases, but the fact that the male patients with the condition never had offspring eluded his notice. In the 1970s, Bjorn Afzelius, a Ph.D. ultrastructuralist from Stockholm, reported cilia immotility in infertile males, some of the cases occurring in families. Half of the cases had Kartagener's triad. The observation of Afzelius was soon applied to children by Jennifer Sturgess, a Ph.D. ultrastructuralist, and her medical colleagues in Toronto. With over 500 MEDLINE references since 1966 on Kartagener's and over 1,000 references on immotile cilia, the causes of the pulmonary infections have become clearer as the patients demonstrate impaired clearance of mucus with resultant sinus and bronchial disease. The cause of the situs inversus remains elusive to this day. It is appropriate to call the condition Kartagener-Afzelius syndrome. |
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Authors:
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Walter E Berdon; Ulrich Willi |
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Publication Detail:
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Type: Biography; Historical Article; Journal Article; Portraits Date: 2003-10-10 |
Journal Detail:
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Title: Pediatric radiology Volume: 34 ISSN: 0301-0449 ISO Abbreviation: Pediatr Radiol Publication Date: 2004 Jan |
Date Detail:
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Created Date: 2004-01-09 Completed Date: 2004-06-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0365332 Medline TA: Pediatr Radiol Country: Germany |
Other Details:
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Languages: eng Pagination: 38-42 Citation Subset: IM |
Affiliation:
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Department of Radiology, Children's Hospital of New York, 3959 Broadway, CHN 3-325, New York, NY 10032, USA. web2@columbia.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Canada Ciliary Motility Disorders / history* History, 20th Century Humans Kartagener Syndrome / history* Sweden Switzerland |
| Personal Name Subject | |
Personal Name Subject:
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Manes Kartagener; Bjorn Afzelius; Jennifer Sturgess |
| Comments/Corrections | |
Comment In:
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Pediatr Radiol. 2004 Jul;34(7):585-6
[PMID:
15164138
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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