Document Detail

Situational reactivity of autonomic functions in schizophrenic patients.
MedLine Citation:
PMID:  6955823     Owner:  NLM     Status:  MEDLINE    
In a study designed to evaluate the state of arousal and the autonomic reactivity to experimental conditions in schizophrenic patients, 12 acute, unmedicated schizophrenic patients with paranoid hallucinatory symptomatology and 63 healthy normal control subjects were administered four standardized tasks: cold pressor test, noise, mental arithmetic, and active relaxation. Biochemical (norepinephrine and cortisol) and physiological (electromyogram, electroencephalogram, skin and conductance response, skin conductance level, finger pulse amplitude, finger temperature, heart rate, respiratory volume, pulse wave velocity, and electrogastrogram) parameters were measured simultaneously. Schizophrenic patients showed elevated levels of cortisol and norepinephrine, as well as heightened responsivity on measures of electromyographic activity, skin conductance level, and heart rate, throughout the trial, and reduced responsivity to conditions of stress. It is concluded that schizophrenic patients show higher nonspecific activation and reduced ability to react to external stimulation, perhaps induced by lack of inhibition of the reticular formation by the limbic system.
M Albus; M Ackenheil; R R Engel; F Müller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatry research     Volume:  6     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1982 Jun 
Date Detail:
Created Date:  1982-10-29     Completed Date:  1982-10-29     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  361-70     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Arousal* / physiology
Galvanic Skin Response / physiology
Heart Rate
Hydrocortisone / blood
Norepinephrine / blood
Schizophrenia, Paranoid / psychology
Schizophrenic Psychology*
Skin Temperature
Reg. No./Substance:
50-23-7/Hydrocortisone; 51-41-2/Norepinephrine

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