Document Detail

Sites of action of fusidic acid in eukaryotes. Inhibition by fusidic acid of a ribosome-independent GTPase from Artemia salina embryos.
MedLine Citation:
PMID:  171159     Owner:  NLM     Status:  MEDLINE    
1. A ribosome-independent GTPase activity has been isolated from the high-speed supernatant fraction of Artemia salina embryos, and some of its properties have been studied. This activity is inhibited by fusidic acid, an antibiotic generally thought to inhibit only EF-2 in eukaryotes. However, several lines of evidence indicate that the GTPase activity, described here, is distinct from EF-2. The results suggest, therefore, that the inhibitory effect of fusidic acid in eukaryotic systems is not restricted to EF-2 (and ribosome)-dependent functions only. 2. The results of other experiments have revealed that, despite its ability to inhibit the GTPase activity mentioned above, fusidic acid is not a non-specific inhibitor of all ribosome-independent GTPase and ATPase activities present in eukaryotic cells.
R Mazumder
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  European journal of biochemistry / FEBS     Volume:  58     ISSN:  0014-2956     ISO Abbreviation:  Eur. J. Biochem.     Publication Date:  1975 Oct 
Date Detail:
Created Date:  1976-02-02     Completed Date:  1976-02-02     Revised Date:  2007-07-23    
Medline Journal Info:
Nlm Unique ID:  0107600     Medline TA:  Eur J Biochem     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  549-54     Citation Subset:  IM    
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MeSH Terms
Adenosine Triphosphatases / antagonists & inhibitors
Crustacea / enzymology*
Dose-Response Relationship, Drug
Fusidic Acid / pharmacology*
GTP Phosphohydrolase-Linked Elongation Factors / antagonists & inhibitors*
Peptide Elongation Factors
Phosphoric Monoester Hydrolases / antagonists & inhibitors*
RNA, Transfer / metabolism
Reg. No./Substance:
0/Peptide Elongation Factors; 63-91-2/Phenylalanine; 6990-06-3/Fusidic Acid; 9014-25-9/RNA, Transfer; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/GTP Phosphohydrolase-Linked Elongation Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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