| Sites of action of fusidic acid in eukaryotes. Inhibition by fusidic acid of a ribosome-independent GTPase from Artemia salina embryos. | |
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MedLine Citation:
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PMID: 171159 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. A ribosome-independent GTPase activity has been isolated from the high-speed supernatant fraction of Artemia salina embryos, and some of its properties have been studied. This activity is inhibited by fusidic acid, an antibiotic generally thought to inhibit only EF-2 in eukaryotes. However, several lines of evidence indicate that the GTPase activity, described here, is distinct from EF-2. The results suggest, therefore, that the inhibitory effect of fusidic acid in eukaryotic systems is not restricted to EF-2 (and ribosome)-dependent functions only. 2. The results of other experiments have revealed that, despite its ability to inhibit the GTPase activity mentioned above, fusidic acid is not a non-specific inhibitor of all ribosome-independent GTPase and ATPase activities present in eukaryotic cells. |
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Authors:
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R Mazumder |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of biochemistry / FEBS Volume: 58 ISSN: 0014-2956 ISO Abbreviation: Eur. J. Biochem. Publication Date: 1975 Oct |
Date Detail:
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Created Date: 1976-02-02 Completed Date: 1976-02-02 Revised Date: 2007-07-23 |
Medline Journal Info:
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Nlm Unique ID: 0107600 Medline TA: Eur J Biochem Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 549-54 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adenosine Triphosphatases
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antagonists & inhibitors Crustacea / enzymology* Dose-Response Relationship, Drug Fusidic Acid / pharmacology* GTP Phosphohydrolase-Linked Elongation Factors / antagonists & inhibitors* Peptide Elongation Factors Phenylalanine Phosphoric Monoester Hydrolases / antagonists & inhibitors* RNA, Transfer / metabolism Ribosomes |
| Chemical | |
Reg. No./Substance:
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0/Peptide Elongation Factors; 63-91-2/Phenylalanine; 6990-06-3/Fusidic Acid; 9014-25-9/RNA, Transfer; EC 3.1.3.-/Phosphoric Monoester Hydrolases; EC 3.6.1.-/Adenosine Triphosphatases; EC 3.6.1.-/GTP Phosphohydrolase-Linked Elongation Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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