| Sites of Ca(2+) wave initiation move with caveolae to the trailing edge of migrating cells. | |
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MedLine Citation:
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PMID: 11861755 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The caveola is a membrane domain that compartmentalizes signal transduction at the cell surface. Normally in endothelial cells, groups of caveolae are found clustered along stress fibers or at the lateral margins in all regions of the cell. Subsets of these clusters appear to contain the signaling machinery for initiating Ca(2+) wave formation. Here we report that induction of cell migration, either by wounding a cell monolayer or by exposing cells to laminar shear stress, causes caveolae to move to the trailing edge of the cell. Concomitant with the relocation of the caveolae, sites of Ca(2+) wave initiation move to the same location. In as much as the relocated caveolae contain elements of the signaling machinery required for ATP-stimulated release of Ca(2+) from the ER, these results suggest that caveolae function as containers that carry this machinery to different cellular locations. |
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Authors:
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Masashi Isshiki; Joji Ando; Kimiko Yamamoto; Toshiro Fujita; Yunshu Ying; Richard G W Anderson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of cell science Volume: 115 ISSN: 0021-9533 ISO Abbreviation: J. Cell. Sci. Publication Date: 2002 Feb |
Date Detail:
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Created Date: 2002-02-25 Completed Date: 2002-12-30 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0052457 Medline TA: J Cell Sci Country: England |
Other Details:
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Languages: eng Pagination: 475-84 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75235-9039, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Adaptor Proteins, Vesicular Transport / metabolism Adenosine Triphosphate / metabolism Animals Calcium / metabolism Calcium Signaling / physiology* Cattle Caveolae / metabolism* Caveolin 1 Caveolins / genetics, metabolism Cell Movement / physiology* Cell Polarity Cells, Cultured Endothelium, Vascular / metabolism*, ultrastructure GTP-Binding Protein alpha Subunits, Gq-G11 Heterotrimeric GTP-Binding Proteins / metabolism Stress, Mechanical Tubulin / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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GM 52016/GM/NIGMS NIH HHS; HL 20948/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins; 0/Adaptor Proteins, Vesicular Transport; 0/Caveolin 1; 0/Caveolins; 0/Tubulin; 56-65-5/Adenosine Triphosphate; 7440-70-2/Calcium; EC 3.6.5.1/GTP-Binding Protein alpha Subunits, Gq-G11; EC 3.6.5.1/Heterotrimeric GTP-Binding Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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