Document Detail


Site-specific differences in the fatty acid composition of human adipose tissue.
MedLine Citation:
PMID:  1487971     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fatty acid composition of triacylglycerols from fifteen distinct adipose depots taken from each of seven adult male human subjects was compared. Oleic, palmitic, linoleic, stearic, myristic, palmitoleic and vaccenic acids accounted for more than 90% of the triacylglycerol fatty acids in all sites from all subjects; a number of other fatty acids were also identified and quantified. There were large differences in the average fatty acid composition between individual subjects. There were no site-specific differences in the proportions of myristic (3.8-4.7% of triacylglycerol fatty acids), palmitic (23-29%), linoleic (6.7-9.8%) or vaccenic (4.1-4.7%) acids or in the proportions of any of the less abundant fatty acids. There were some significant site-specific differences in the proportions of palmitoleic, oleic and stearic acids. The calf depot contained more palmitoleic acid (6.41 +/- 1.09%) than the trapezius (3.12 +/- 0.55%), perirenal (3.59 +/- 0.50%) and mesenteric (3.70 +/- 0.43%) depots, more oleic acid (42.13 +/- 1.27%) than the trapezius (36.03 +/- 2.18%), perirenal (36.50 +/- 1.56%) and breast (37.13 +/- 1.55%) depots and less stearic acid (5.18 +/- 0.89%) than the trapezius (8.57 +/- 0.97%), perirenal (8.49 +/- 0.75%), mesenteric (7.87 +/- 0.42%), breast (8.02 +/- 0.75%) and clavicular (8.34 +/- 0.78%) depots. The buttock depot contained less stearic acid (6.06 +/- 0.65%) than the perirenal, mesenteric and clavicular depots, while the anterior thigh depot contained less stearic acid (6.07 +/- 0.70%) than the perirenal depot. These findings indicate that, while most human adipose depots differ little in fatty acid composition, some sites, in particular the calf, perirenal, trapezius and mesenteric depots, have site-specific properties.
Authors:
P C Calder; D J Harvey; C M Pond; E A Newsholme
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Lipids     Volume:  27     ISSN:  0024-4201     ISO Abbreviation:  Lipids     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-02-19     Completed Date:  1993-02-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0060450     Medline TA:  Lipids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  716-20     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, University of Oxford, United Kingdom.
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MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / chemistry*
Fatty Acids / analysis*
Fatty Acids, Unsaturated / analysis
Humans
Male
Tissue Distribution
Triglycerides / chemistry*
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Triglycerides

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