Document Detail


Site-specific differences in the fatty acid composition of abdominal adipose tissue in an obese population from a Mediterranean area: relation with dietary fatty acids, plasma lipid profile, serum insulin, and central obesity.
MedLine Citation:
PMID:  11684525     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Abdominal obesity is associated with coronary risk, although causality is not well established. OBJECTIVE: In an obese Mediterranean population, we measured the fatty acid composition of adipose tissue, its relation with dietary fatty acids and central fat deposition, and its influence on plasma lipids and insulin. DESIGN: Adipose tissue samples were obtained from 84 obese patients (29 men, 55 women) aged 30-70 y (body mass index, in kg/m(2): 27-35). We measured concentrations of insulin and lipids in plasma and fatty acids in subcutaneous, omental, and perivisceral fat. Dietary fatty acid intake was assessed with a 7-d diet record. RESULTS: The population studied was normolipidemic and normoinsulinemic. There were important differences in fatty acid composition between tissue sites: saturated fatty acids were higher and monounsaturated fatty acids were lower in perivisceral than in subcutaneous fat (P < 0.05). Significant correlations were found for oleic, linoleic, alpha-linolenic, and total n-6 polyunsaturated fatty acids between the subject's habitual diet and adipose tissue composition. Oleic and n-3 fatty acids from adipose regions were negatively correlated with apolipoprotein B and triacylglycerols; adipose tissue 22:1n-9, 20:2n-6, stearic acid, and eicosapentaenoic acid were positively correlated with HDL and apolipoprotein A; and adipose tissue myristic acid was negatively correlated with apolipoprotein A (P < 0.05). Central obesity was positively associated with n-6 polyunsaturated fatty acids and inversely associated with monounsaturated fatty acids and n-3 polyunsaturated fatty acids in adipose tissue (P < 0.05). CONCLUSION: The differences found in the composition and metabolism of perivisceral, omental, and subcutaneous fats may indicate that their atherogenic capacities also differ.
Authors:
M Garaulet; F Pérez-Llamas; M Pérez-Ayala; P Martínez; F S de Medina; F J Tebar; S Zamora
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  74     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2001-12-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  585-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Physiology and Pharmacology, University of Murcia, Murcia, Spain.
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MeSH Terms
Descriptor/Qualifier:
Abdomen / anatomy & histology
Adipose Tissue / anatomy & histology,  chemistry*,  metabolism
Adult
Aged
Body Composition
Body Mass Index
Diet
Diet Records
Dietary Fats / administration & dosage*,  metabolism
Fatty Acids / administration & dosage,  analysis*,  metabolism
Fatty Acids, Monounsaturated / administration & dosage,  metabolism
Fatty Acids, Unsaturated / administration & dosage,  metabolism
Female
Humans
Insulin / blood*
Lipids / blood*
Male
Middle Aged
Obesity / metabolism*
Spain
Chemical
Reg. No./Substance:
0/Dietary Fats; 0/Fatty Acids; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 0/Lipids; 11061-68-0/Insulin
Comments/Corrections
Comment In:
Am J Clin Nutr. 2002 Jun;75(6):1123; author reply 1124   [PMID:  12036825 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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