Document Detail

Site-specific assembly of DNA and appended cargo on arrayed carbon nanotubes.
MedLine Citation:
PMID:  15469250     Owner:  NLM     Status:  MEDLINE    
We describe a strategy that permits discrete regions of arrayed carbon nanotubes (CNTs) to be functionalized simultaneously and specifically with DNA oligonucleotides. The different chemical properties of two regions on single CNTs and orthogonal chemical coupling strategies have been exploited to derivatize CNTs within highly ordered arrays with multiple DNA sequences. Through duplex hybridization, we then targeted different DNA sequences with appended metal nanoparticles to distinct sites on the CNT architecture with precise spatial control. The materials generated from these studies represent the first CNTs with bipartite functionalization. The approach described provides a high level of precision in parallel and directed assembly of DNA sequences and appended cargo and is useful for the preparation of novel hybrid bionanomaterials.
Bradford J Taft; Adam D Lazareck; Gary D Withey; Aijun Yin; J M Xu; Shana O Kelley
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  126     ISSN:  0002-7863     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-07     Completed Date:  2005-04-14     Revised Date:  2008-01-17    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  12750-1     Citation Subset:  IM    
Department of Chemistry, Boston College, Chestnut Hill, MA 02467, USA.
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MeSH Terms
DNA / chemical synthesis*,  chemistry
DNA, Single-Stranded / chemical synthesis,  chemistry
Microscopy, Electron, Scanning
Nanotubes, Carbon / chemistry*
Oligonucleotides / chemical synthesis,  chemistry
Pyrenes / chemistry
Reg. No./Substance:
0/DNA, Single-Stranded; 0/Nanotubes, Carbon; 0/Oligonucleotides; 0/Pyrenes; 9007-49-2/DNA

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