| Site and mechanics of spontaneous, sleep-associated obstructive apnea in infants. | |
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MedLine Citation:
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PMID: 11090602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To examine the mechanics of infantile obstructive sleep apnea (OSA), airway pressures were measured using a triple-lumen catheter in 19 infants (age 1-36 wk), with concurrent overnight polysomnography. Catheter placement was guided by correlations between measurements of magnetic resonance images and body weight of 70 infants. The level of spontaneous obstruction was palatal in 52% and retroglossal in 48% of all events. Palatal obstruction predominated in infants treated for OSA (80% of events), compared with 38.6% from infants with infrequent events (P = 0.02). During obstructive events, successive respiratory efforts increased in amplitude (mean intrathoracic pressures -11.4, -15.0, and -20.4 cmH(2)O; ANOVA, P < 0.05), with arousal after only 29% of the obstructive and mixed apneas. The soft palate is commonly involved in the upper airway obstruction of infants suffering OSA. Postterm, infant responses to upper airway obstruction are intermediate between those of preterm infants and older children, with infrequent termination by arousal but no persisting "upper airway resistance" and respiratory efforts exceeding baseline during the event. |
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Authors:
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G W Don; T Kirjavainen; C Broome; C Seton; K A Waters |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 89 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 2000 Dec |
Date Detail:
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Created Date: 2000-12-26 Completed Date: 2001-01-11 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 2453-62 Citation Subset: IM |
Affiliation:
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David Read Sleep Unit, Department of Respiratory Medicine, The Royal Alexandra Hospital for Children, Westmead, New South Wales, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Airway Obstruction
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physiopathology Arousal Female Humans Infant Infant, Newborn Magnetic Resonance Imaging Male Models, Anatomic Mouth / anatomy & histology Pharynx / anatomy & histology Polysomnography Respiration Respiratory Mechanics* Sleep Apnea Syndromes / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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