| Site-dependent differences in collagen lamellae in the corneal substantia propria of beagle dogs. | |
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MedLine Citation:
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PMID: 19801905 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The fine structure in the center and periphery of the cornea of 16 beagle dogs were characterized and compared. The central cornea (about 540 microm) was apparently thinner than the peripheral cornea (about 720 microm). Thickness ratios of the corneal substantia propria to the entire cornea were approximately 86% in both portions. In addition, number of collagen lamellae, collagen fibril diameter, and collagen fibril index of the central substantia propria are different from those of the periphery (253 vs 236 lamellae, 29.1 vs 32.0 nm, and 39.0 vs 41.6%, respectively). These differences are thought to be due to site-dependent accumulation of proteoglycans (decorin and lumican) which are responsible for production of thin fibrils. The central portion with higher proteoglycans would have abundant thin fibrils with less slippage but better elasticity to buffer against the direct impact of intraocular pressure on the cornea. In contrast, thick fibrils in the peripheral substantia propria would contribute to the maintenance of tensile strength acting on the transition zone between the cornea and sclera. |
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Authors:
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Aya Nagayasu; Tomoe Hirayanagi; Yuji Tanaka; Prasarn Tangkawattana; Hiromi Ueda; Kazushige Takehana |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of veterinary medical science / the Japanese Society of Veterinary Science Volume: 71 ISSN: 0916-7250 ISO Abbreviation: J. Vet. Med. Sci. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-10-05 Completed Date: 2009-11-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105360 Medline TA: J Vet Med Sci Country: Japan |
Other Details:
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Languages: eng Pagination: 1229-31 Citation Subset: IM |
Affiliation:
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Department of Veterinary Anatomy, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Collagen / ultrastructure* Cornea / ultrastructure* Dogs Male Tensile Strength |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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