Document Detail

Sister-chromatid exchanges in newborns after normal and progesterone-treated pregnancies.
MedLine Citation:
PMID:  3600694     Owner:  NLM     Status:  MEDLINE    
Two groups of newborns were selected for SCE analyses, one consisting of infants born after progesterone-treatment during pregnancy (PTP) and a control group. A slight, but statistically significant difference in the number of SCEs was found: in the control group 5.55 +/- 0.62, and in the PTP group 7.99 +/- 0.88. This effect also proved to be true in an in vitro system, where various concentrations of progesterone were tested. The authors offer two possible explanations: one involving the biochemical pathways of progesterone and the influence on the level of excretory products; the other involving a direct relationship between progesterone and DNA.
B Lukić; N Barjaktarović
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  191     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1987 Jun 
Date Detail:
Created Date:  1987-07-29     Completed Date:  1987-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  121-4     Citation Subset:  IM    
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MeSH Terms
DNA Damage*
Infant, Newborn
Lymphocytes / ultrastructure
Maternal-Fetal Exchange
Pancuronium / administration & dosage,  analogs & derivatives*,  pharmacology
Pregnancy Complications / drug therapy
Progesterone / administration & dosage,  metabolism,  pharmacology*
Sister Chromatid Exchange / drug effects*
Reg. No./Substance:
0/Pancuronium; 43021-45-0/dacuronium; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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