Document Detail

Sister-chromatid exchanges and chromosal breakage in patients treated with cytostatics.
MedLine Citation:
PMID:  481454     Owner:  NLM     Status:  MEDLINE    
The frequency of structural chromosomal rearrangements and sister-chromatid exchanges (SCEs) was investigated in short-term phytohemagglutininstimulated lymphocyte cultures by means of bromodeoxyuridine substitution and fluorescence plus Giemsa (FPG) staining technique. Both these parameters were significantly increased in patients treated with comparatively low doses of cyclophosphamide, busulphan and adriamycin. The increased SCE rate was proportional to the number of chromosome breaks, the ratio of SCE to breaks being about 100:1. The increase in the SCE number was maintained for several months after the termination of cytostatic therapy, when the conventional analysis of chromosome breaks yielded normal results. Normal SCE values were obtained in two patients treated with low doses of fluorouracil.
J Musilová; K Michalová; J Urban
Related Documents :
864784 - Cytogenetic investigations on lymphocytes from workers exposed to vinyl chloride.
406414 - Sister chromatid exchange and chromosome aberration analysis with the use of several ca...
3683434 - Chromosome aberrations in workers at a tannery in iraq.
6785204 - Sister chromatid exchanges and heterochromatin.
11420234 - Cellular and morphological traits of oocytes retrieved from aging mice after exogenous ...
7234904 - Duplication of distal 11q and 22p occurrence in two unrelated families.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  67     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Busulfan / therapeutic use*
Chromatids / drug effects*
Chromosome Aberrations*
Cyclophosphamide / therapeutic use*
Doxorubicin / therapeutic use*
Fluorouracil / pharmacology
Neoplasms / drug therapy
Reg. No./Substance:
23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 55-98-1/Busulfan; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Absence of genotoxic effects of metronidazole and two of its urinary metabolites on human lymphocyte...
Next Document:  Activity of citrinin metabolized by rat and human microsome fractions in clastogenicity and SCE assa...