Document Detail


Sister-chromatid exchanges and chromosal breakage in patients treated with cytostatics.
MedLine Citation:
PMID:  481454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency of structural chromosomal rearrangements and sister-chromatid exchanges (SCEs) was investigated in short-term phytohemagglutininstimulated lymphocyte cultures by means of bromodeoxyuridine substitution and fluorescence plus Giemsa (FPG) staining technique. Both these parameters were significantly increased in patients treated with comparatively low doses of cyclophosphamide, busulphan and adriamycin. The increased SCE rate was proportional to the number of chromosome breaks, the ratio of SCE to breaks being about 100:1. The increase in the SCE number was maintained for several months after the termination of cytostatic therapy, when the conventional analysis of chromosome breaks yielded normal results. Normal SCE values were obtained in two patients treated with low doses of fluorouracil.
Authors:
J Musilová; K Michalová; J Urban
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  67     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1979-11-21     Completed Date:  1979-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  289-94     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Bromodeoxyuridine
Busulfan / therapeutic use*
Chromatids / drug effects*
Chromosome Aberrations*
Cyclophosphamide / therapeutic use*
Doxorubicin / therapeutic use*
Fluorouracil / pharmacology
Humans
Neoplasms / drug therapy
Chemical
Reg. No./Substance:
23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 51-21-8/Fluorouracil; 55-98-1/Busulfan; 59-14-3/Bromodeoxyuridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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