| Sister chromatid exchange and lymphocyte proliferation in a Down syndrome mosaic. | |
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MedLine Citation:
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PMID: 6220843 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The number of SCE was compared in the normal and trisomic cell lines of a trisomy 21 mosaic case. It was found that in the trisomic cells the SCE-frequency was twice as high as in the normal cells. The mitoses with high numbers of SCE (above 10) were increased 4-5 fold. Differential chromatid staining also allowed us to determine the mitotic cycle of the mitoses. The percentage of mitoses from the fourth or a later mitotic cycle was significantly higher in the trisomic cell line than in the normal one. From this result, it can be concluded that the cell cycle time was distinctly shortened in the cells with trisomy 21. |
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Authors:
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A Heidemann; B Schmalenberger; H Zankl |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Clinical genetics Volume: 23 ISSN: 0009-9163 ISO Abbreviation: Clin. Genet. Publication Date: 1983 Feb |
Date Detail:
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Created Date: 1983-06-17 Completed Date: 1983-06-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0253664 Medline TA: Clin Genet Country: DENMARK |
Other Details:
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Languages: eng Pagination: 139-42 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cells, Cultured Child, Preschool Down Syndrome / genetics*, immunology Humans Lymphocyte Activation Male Mitosis Mosaicism* Sister Chromatid Exchange |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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