Document Detail

Sister chromatid exchange and growth kinetics in chronic myeloid leukemia.
MedLine Citation:
PMID:  6953996     Owner:  NLM     Status:  MEDLINE    
The frequency of sister chromatid exchange (SCE) was analyzed in bone marrow cells of 16 patients with chronic myeloid leukemia. We have compared the SCE frequency in these patients, in both chronic and blastic phases of the disease, to that of normal individuals. The frequency of SCE in blastic-phase chronic myeloid leukemia patients (mean, 1.86/cell) was significantly lower than that in chronic phase (mean, 2.96/cell), which was in turn lower than that in normal individuals (mean, 4.108/cell). We have used the SCE data to compare the rates of division of the bone marrow cells. Cells from chronic myeloid leukemia patients divided more slowly than did those from normal individuals, those from blastic-phase patients being slowest.
C Stoll; F Oberling; M P Roth
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  42     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1982 Aug 
Date Detail:
Created Date:  1982-09-10     Completed Date:  1982-09-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3240-3     Citation Subset:  IM    
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MeSH Terms
Bone Marrow / pathology
Cell Division
Crossing Over, Genetic*
Leukemia, Myeloid / genetics,  physiopathology*
Leukemia, Myeloid, Acute / genetics,  physiopathology
Middle Aged
Sister Chromatid Exchange*

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