| Sister chromatid exchange and chromosome aberrations induced by curcumin and tartrazine on mammalian cells in vivo. | |
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MedLine Citation:
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PMID: 2209081 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sister chromatid exchanges (SCEs) and chromosomal aberrations induced by curcumin (a natural dye) and tartrazine (a synthetic dye) were studied on bone marrow cells of mice and rats following acute and chronic exposure via the diet. Except for two low concentrations in the curcumin and one low concentration in the tartrazine treated series a significant increase in SCEs was observed in all the concentrations of the two dyes tested. Except for two high concentrations during the 9 months treatment no significant increase in chromosomal aberrations was observed in the curcumin treated series, whereas tartrazine showed a significant increase in chromosomal aberrations in some of the higher concentrations in all the series tested. The results indicate that tartrazine is more clastogenic than curcumin. |
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Authors:
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A K Giri; S K Das; G Talukder; A Sharma |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cytobios Volume: 62 ISSN: 0011-4529 ISO Abbreviation: Cytobios Publication Date: 1990 |
Date Detail:
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Created Date: 1990-11-07 Completed Date: 1990-11-07 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207227 Medline TA: Cytobios Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 111-7 Citation Subset: IM |
Affiliation:
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College of Pharmacy, University of Michigan, Ann Arbor 48109. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bone Marrow / drug effects Bone Marrow Cells* Chromosome Aberrations* Curcumin / pharmacology* Dose-Response Relationship, Drug Male Mice Rats Sister Chromatid Exchange / drug effects* Tartrazine / pharmacology* |
| Chemical | |
Reg. No./Substance:
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1934-21-0/Tartrazine; 458-37-7/Curcumin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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