| Sister Chromatid Cohesion. | |
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MedLine Citation:
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PMID: 23043155 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation. Cohesion is mediated by cohesin complexes that are thought to embrace sister chromatids as large rings. Cohesin binds to DNA dynamically before DNA replication and is converted into a stably DNA-bound form during replication. This conversion requires acetylation of cohesin, which in vertebrates leads to recruitment of sororin. Sororin antagonizes Wapl, a protein that is able to release cohesin from DNA, presumably by opening the cohesin ring. Inhibition of Wapl by sororin therefore "locks" cohesin rings on DNA and allows them to maintain cohesion for long periods of time in mammalian oocytes, possibly for months or even years. |
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Authors:
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Jan-Michael Peters; Tomoko Nishiyama |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-6 |
Journal Detail:
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Title: Cold Spring Harbor perspectives in biology Volume: - ISSN: 1943-0264 ISO Abbreviation: Cold Spring Harb Perspect Biol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-8 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101513680 Medline TA: Cold Spring Harb Perspect Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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IMP, Dr. Bohr-Gasse 7, A-1030 Vienna, Austria. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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