Document Detail

Sister chromatid cohesion.
MedLine Citation:
PMID:  23043155     Owner:  NLM     Status:  MEDLINE    
During S phase, not only does DNA have to be replicated, but also newly synthesized DNA molecules have to be connected with each other. This sister chromatid cohesion is essential for the biorientation of chromosomes on the mitotic or meiotic spindle, and is thus an essential prerequisite for chromosome segregation. Cohesion is mediated by cohesin complexes that are thought to embrace sister chromatids as large rings. Cohesin binds to DNA dynamically before DNA replication and is converted into a stably DNA-bound form during replication. This conversion requires acetylation of cohesin, which in vertebrates leads to recruitment of sororin. Sororin antagonizes Wapl, a protein that is able to release cohesin from DNA, presumably by opening the cohesin ring. Inhibition of Wapl by sororin therefore "locks" cohesin rings on DNA and allows them to maintain cohesion for long periods of time in mammalian oocytes, possibly for months or even years.
Jan-Michael Peters; Tomoko Nishiyama
Related Documents :
16793385 - Assays for nonhomologous end joining in extracts.
19671525 - Mechanism of dna substrate recognition by the mammalian dna repair enzyme, polynucleoti...
15105825 - Shorter telomeres, accelerated ageing and increased lymphoma in dna-pkcs-deficient mice.
11859125 - Transient association of ku with nuclear substrates characterized using fluorescence ph...
8984005 - Cloning and mapping of variety-specific rice genomic dna sequences: amplified fragment ...
16120385 - Direct effects of nucleoside reverse transcriptase inhibitors on rat cardiac mitochondr...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-01
Journal Detail:
Title:  Cold Spring Harbor perspectives in biology     Volume:  4     ISSN:  1943-0264     ISO Abbreviation:  Cold Spring Harb Perspect Biol     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-05     Completed Date:  2013-04-15     Revised Date:  2014-11-05    
Medline Journal Info:
Nlm Unique ID:  101513680     Medline TA:  Cold Spring Harb Perspect Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptor Proteins, Signal Transducing / metabolism
Biological Evolution*
Carrier Proteins / metabolism
Cell Cycle Proteins / metabolism*,  physiology
Chromatids / physiology*
Chromosomal Proteins, Non-Histone / metabolism*,  physiology
DNA / metabolism*
DNA Replication / physiology*
Macromolecular Substances / metabolism*
Nuclear Proteins / metabolism
Proto-Oncogene Proteins / metabolism
Species Specificity
Reg. No./Substance:
0/Adaptor Proteins, Signal Transducing; 0/CDCA5 protein, human; 0/Carrier Proteins; 0/Cell Cycle Proteins; 0/Chromosomal Proteins, Non-Histone; 0/Macromolecular Substances; 0/Nuclear Proteins; 0/Proto-Oncogene Proteins; 0/WAPAL protein, human; 0/cohesins; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Efficiency of using community organisations as catalysts for recruitment to continence promotion tri...
Next Document:  Optogenetic strategies to dissect the neural circuits that underlie reward and addiction.