Document Detail

Sirtuin1 in tracheal aspirate leukocytes: possible role in the development of bronchopulmonary dysplasia in premature infants.
MedLine Citation:
PMID:  22272724     Owner:  NLM     Status:  Publisher    
Objective: To study the association between Sirtuin1 (Sirt1), a class III histone deacetylator, in tracheal aspirate (TA) leukocytes and the development of bronchopulmonary dysplasia (BPD) in premature infants and modulation of Sirt1 with dexamethasone (Dex) use. Design/methods: Serial TA samples were collected on days 1, 3, 5 and 7 from ventilated premature neonates. Sirt1 was localized by immunocytochemistry and quantified on a scale of 0-4 by blinded observers. BPD was defined as the need of supplemental oxygen at 36 weeks postmenstrual age (PMA). Results: A total of 130 TA samples were collected from 51 infants (mean ± SD: GA 25.5 ± 1.4 w, BW 762 ± 174 g). Eleven infants survived without BPD and 40 infants died before 36 weeks PMA or developed BPD. Sirt1 was localized in the cytoplasm and nuclei of mononuclear (MONO) as well as polymorphonuclear cells. Sirt1 was significantly more localized in the nuclei of MONO cells in infants without BPD compared to infants who developed BPD or died before 36 weeks PMA. Twenty six infants received Dex. There was no significant change in Sirt1 localization with steroid therapy. Conclusions: Lower Sirt1 in TA leukocytes is associated with the development of BPD or death in premature infants. Dex use had no effect on Sirt1.
Kartik Mody; Judy G Saslow; Suganya Kathiravan; Riva Eydelman; Vishwanath Bhat; Gary E Stahl; Kee Pyon; Vineet Bhandari; Zubair H Aghai
Related Documents :
22644794 - Risk factors associated with the need for a tracheostomy in extremely low birth weight ...
24626374 - Handling of preterm infants in a neonatal intensive care unit.
22092914 - Emotional responses of mothers of late-preterm and term infants.
24147974 - Respiratory function parameters in ventilated newborn infants undergoing whole body hyp...
515734 - Metabolism of theophylline to caffeine in human fetal liver.
21243534 - Necrotizing enterocolitis in a term neonate following intravenous immunoglobulin therapy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-25
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  -     ISSN:  1476-4954     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of Pediatrics, Cooper University Hospital-UMDNJ-Robert Wood Johnson Medical School , Camden, NJ 08103.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Further evidence for the likely completeness of the library of solved single domain protein structur...
Next Document:  The Impact of the Activated Stroma on Pancreatic Ductal Adenocarcinoma Biology and Therapy Resistanc...