| Sirtuin-1 regulation of mammalian metabolism. | |
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MedLine Citation:
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PMID: 20971038 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Sirtuin-1 (SirT1) is a nutrient-sensing deacetylase whose levels and activity increase with caloric restriction to preserve euglycemia and promote efficient energy utilization. Focusing on data obtained in vivo, we review how SirT1 orchestrates the adaptive response to fasting by stimulating hepatic gluconeogenesis and fatty acid oxidation, increasing circulating adiponectin levels and limiting immune activation. Finally, we consider its viability as a therapeutic target for the treatment of type 2 diabetes. |
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Authors:
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Matthew P Gillum; Derek M Erion; Gerald I Shulman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-10-21 |
Journal Detail:
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Title: Trends in molecular medicine Volume: - ISSN: 1471-499X ISO Abbreviation: - Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966035 Medline TA: Trends Mol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Medicine and Cellular & Molecular Physiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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