Document Detail

Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis.
MedLine Citation:
PMID:  23329826     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to evaluate the role of sirtuin 1 (SirT1) in exercise- and resveratrol (RSV)-induced skeletal muscle mitochondrial biogenesis. Using muscle-specific SirT1-deficient (KO) mice and a cell culture model of differentiated myotubes, we compared the treatment of resveratrol, an activator of SirT1, with that of exercise in inducing mitochondrial biogenesis. These experiments demonstrated that SirT1 plays a modest role in maintaining basal mitochondrial content and a larger role in preserving mitochondrial function. Furthermore, voluntary exercise and RSV treatment induced mitochondrial biogenesis in a SirT1-independent manner. However, when RSV and exercise were combined, a SirT1-dependent synergistic effect was evident, leading to enhanced translocation of PGC-1α and SirT1 to the nucleus and stimulation of mitochondrial biogenesis. Thus, the magnitude of the effect of RSV on muscle mitochondrial biogenesis is reliant on SirT1, as well as the cellular environment, such as that produced by repeated bouts of exercise.
Keir J Menzies; Kaustabh Singh; Ayesha Saleem; David A Hood
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-17
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  288     ISSN:  1083-351X     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-11     Completed Date:  2013-04-30     Revised Date:  2014-03-11    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6968-79     Citation Subset:  IM    
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MeSH Terms
AMP-Activated Protein Kinases / metabolism
Active Transport, Cell Nucleus / drug effects
Cell Line
Cell Nucleus / drug effects,  metabolism
Mice, Knockout
Mice, Transgenic
Microscopy, Fluorescence
Mitochondria, Muscle / drug effects*,  metabolism
Muscle Contraction / drug effects
Muscle Fibers, Skeletal / drug effects,  metabolism,  physiology
Muscle, Skeletal / drug effects,  metabolism,  physiology
Phosphorylation / drug effects
Physical Conditioning, Animal / physiology*
Reactive Oxygen Species / metabolism
Sirtuin 1 / genetics,  metabolism*
Stilbenes / pharmacology*
Trans-Activators / metabolism
Transcription Factors
Vasodilator Agents / pharmacology
p38 Mitogen-Activated Protein Kinases / metabolism
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/Ppargc1a protein, mouse; 0/Reactive Oxygen Species; 0/Stilbenes; 0/Trans-Activators; 0/Transcription Factors; 0/Vasodilator Agents; EC Protein Kinases; EC Mitogen-Activated Protein Kinases; EC 3.5.1.-/Sirtuin 1; Q369O8926L/resveratrol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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