| Sirolimus versus bare metal stent implantation in patients with total coronary occlusions: subgroup analysis of the Stenting Coronary Arteries in Non-Stress/Benestent Disease (SCANDSTENT) trial. | |
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MedLine Citation:
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PMID: 17070149 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Coronary restenosis is more common in a total coronary occlusion (TCO) than other lesion types after implantation of bare metal stents (BMS). But whereas sirolimus-eluting stents (SES) have been shown to improve the outcomes in simple coronary artery lesions, data on their efficacy in complex coronary lesions are scarce. METHODS: We enrolled 127 patients with coronary artery disease and a TCO > or = 15 mm in length to have either SES or BMS implanted after successful recanalization. Outcome measures included the minimal lumen diameter, the late lumen loss, and angiographic restenosis (> 50% diameter stenosis) at 6 months follow-up and the occurrence of target vessel failure during a 7-month period. RESULTS: The patients were well matched in demographic and angiographic baseline characteristics, and 20% had diabetes. The reference vessel was 2.92 mm in mean, and the lesion length was 25.2 mm. At follow-up, patients who received SES had a minimal lumen diameter of 2.49 mm compared with 1.46 mm in those who received BMS (P = .015), 0% versus 38% developed restenosis (P < .001), lumen loss was -0.05 versus 0.99 mm (P < .001), and the target vessel failure rate 5% with SES versus 35% with BMS (P < .001). Stent thrombosis occurred in 1 patient in the BMS group. CONCLUSIONS: Implantation of SES is safe, and it markedly reduces angiographic restenosis and the occurrence of adverse events in patients with a TCO. |
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Authors:
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Henning Kelbaek; Steffen Helqvist; Leif Thuesen; Lene Kløvgaard; Erik Jørgensen; Kari Saunamäki; Lars R Krusell; Hans E Bøtker; Thomas Engstrøm; Gunnar V H Jensen; |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 152 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2006-11-30 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 882-6 Citation Subset: AIM; IM |
Affiliation:
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Cardiac Cath.Lab., Rigshospitalet, Copenhagen, Denmark. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Angioplasty, Transluminal, Percutaneous Coronary Blood Vessel Prosthesis Implantation Coronary Artery Disease / therapy* Coronary Restenosis / prevention & control* Drug Administration Routes Drug Delivery Systems Female Humans Immunosuppressive Agents / administration & dosage* Male Middle Aged Randomized Controlled Trials as Topic Sirolimus / administration & dosage* Stents* |
| Chemical | |
Reg. No./Substance:
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0/Immunosuppressive Agents; 53123-88-9/Sirolimus |
| Comments/Corrections | |
Comment In:
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Am Heart J. 2006 Nov;152(5):807-9
[PMID:
17070136
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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