| Sirolimus- versus paclitaxel-eluting stents for the treatment of cardiac allograft vasculopathy. | |
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MedLine Citation:
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PMID: 20398863 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: The aim of this study was to compare outcomes after percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) in the treatment of cardiac allograft vasculopathy (CAV). BACKGROUND: PCI in patients with CAV is associated with increased rates of restenosis compared with PCI in patients without CAV. There are no dedicated studies on the influence of different drug-eluting stents (DES) on the outcomes of patients with CAV. METHODS: This is a retrospective observational study of 108 consecutive patients with CAV who underwent PCI with SES and PES at UCLA Medical Center and University of Padova Medical Center between 2002 and 2008. RESULTS: Baseline characteristics were similar among SES (n = 68) and PES (n = 40) patients with the exception of older patients, larger minimal lumen diameter, and smaller diameter stenosis in the SES-treated patients. Angiographic follow-up at 1 year was high in the SES and PES groups (74% vs. 76%, p = 0.8). The SES and PES groups had similar binary restenosis rates (10% vs. 9%, p = 0.7), percent diameter stenosis (24 +/- 24% vs. 24 +/- 18%, p = 0.94), and late lumen loss (0.67 +/- 1.03 mm vs. 0.68 +/- 1.11 mm, p > 0.9). One-year clinical outcomes were not significantly different among CAV patients treated with either SES or PES (major adverse cardiac events: 10% vs. 15%, p = 0.5; death: 3% vs. 5%, p = 0.4; myocardial infarction: 3% vs. 5%, p = 0.4; target vessel revascularization: 4% vs. 8%, p = 0.3). CONCLUSIONS: In patients who underwent PCI for CAV, both SES and PES were safe and effective with no significant differences in clinical and angiographic outcomes. Randomized clinical trials comparing different DES with longer follow-up are necessary to identify the optimal treatment strategy for patients with CAV. |
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Authors:
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Michael S Lee; Giuseppe Tarantini; Jola Xhaxho; Tae Yang; Ashkan Ehdaie; Ravi Bhatia; Enrico Favaretto; Jonathan Tobis |
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Publication Detail:
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Type: Comparative Study; Journal Article; Multicenter Study |
Journal Detail:
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Title: JACC. Cardiovascular interventions Volume: 3 ISSN: 1876-7605 ISO Abbreviation: JACC Cardiovasc Interv Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-19 Completed Date: 2010-07-09 Revised Date: 2012-08-29 |
Medline Journal Info:
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Nlm Unique ID: 101467004 Medline TA: JACC Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 378-82 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiology, UCLA Medical Center, Los Angeles, California 90095, USA. mslee@mednet.ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioplasty, Balloon, Coronary / adverse effects, instrumentation* Cardiovascular Agents / administration & dosage* Chi-Square Distribution Coronary Angiography Coronary Restenosis / etiology Coronary Stenosis / drug therapy, etiology, mortality, radiography, therapy* Drug-Eluting Stents* Female Heart Transplantation / adverse effects*, mortality Humans Italy Los Angeles Male Middle Aged Myocardial Infarction Paclitaxel / administration & dosage* Prosthesis Design Retrospective Studies Severity of Illness Index Sirolimus / administration & dosage* Thrombosis / etiology Time Factors Transplantation, Homologous Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 33069-62-4/Paclitaxel; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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