Document Detail

Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis.
MedLine Citation:
PMID:  18159100     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. METHODS AND RESULTS: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as > or =50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). CONCLUSIONS: Even if treated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI.
Toru Aoyama; Hideki Ishii; Takanobu Toriyama; Hiroshi Takahashi; Hirotake Kasuga; Ryuichiro Murakami; Tetsuya Amano; Tadayuki Uetani; Yoshinari Yasuda; Yukio Yuzawa; Shoichi Maruyama; Seiichi Matsuo; Tatsuaki Matsubara; Toyoaki Murohara
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Circulation journal : official journal of the Japanese Circulation Society     Volume:  72     ISSN:  1346-9843     ISO Abbreviation:  Circ. J.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-26     Completed Date:  2008-03-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101137683     Medline TA:  Circ J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  56-60     Citation Subset:  IM    
Department of Cardiology, Nagoya Kyoritsu Hospital, Showa-ku, Nagoya, Japan.
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MeSH Terms
Coronary Angiography
Coronary Disease / surgery,  therapy
Coronary Restenosis
Drug-Eluting Stents / standards*
Kidney Failure, Chronic / complications*,  therapy
Middle Aged
Renal Dialysis
Sirolimus / administration & dosage*
Stents / standards*
Reg. No./Substance:

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