| Sirolimus-eluting stents vs bare metal stents for coronary intervention in Japanese patients with renal failure on hemodialysis. | |
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MedLine Citation:
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PMID: 18159100 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Accelerated atherosclerosis is a major risk for long-term survivors receiving hemodialysis (HD), with coronary events being the leading cause of mortality. METHODS AND RESULTS: A total of 88 consecutive patients on HD (121 lesions) who underwent percutaneous coronary intervention (PCI) with sirolimus-eluting stents (SES) were compared with 78 patients on HD (95 lesions) who received bare metal stents (BMS) in the preceding 1 year. The primary endpoint was angiographic restenosis defined as > or =50% diameter stenosis at 6-8 months follow-up after PCI. The angiographic restenosis rate at follow-up was 22.2% in the SES group and 24.4% in the BMS group. No difference was detected in the restenosis rate between the 2 groups (p=0.73). When including both HD and non-HD patients, the independent predictors for restenosis after SES implantation were treatment with HD (hazard ratio (HR) 3.12; 95% confidence interval (CI) 1.23-7.95; p=0.016), incidence of hyperlipidemia (HR 3.93; 95%CI 1.12-13.7; p=0.032), coronary calcification (HR 2.78; 95%CI 1.12-6.91; p=0.027), and implantation of multi-stents (HR 4.14; 95%CI 1.70-10.1; p=0.0017). CONCLUSIONS: Even if treated with SES, patients with end-stage renal failure on HD are at high risk of restenosis after PCI. |
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Authors:
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Toru Aoyama; Hideki Ishii; Takanobu Toriyama; Hiroshi Takahashi; Hirotake Kasuga; Ryuichiro Murakami; Tetsuya Amano; Tadayuki Uetani; Yoshinari Yasuda; Yukio Yuzawa; Shoichi Maruyama; Seiichi Matsuo; Tatsuaki Matsubara; Toyoaki Murohara |
Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Circulation journal : official journal of the Japanese Circulation Society Volume: 72 ISSN: 1346-9843 ISO Abbreviation: Circ. J. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2007-12-26 Completed Date: 2008-03-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101137683 Medline TA: Circ J Country: Japan |
Other Details:
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Languages: eng Pagination: 56-60 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Nagoya Kyoritsu Hospital, Showa-ku, Nagoya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Calcinosis Coronary Angiography Coronary Disease / surgery, therapy Coronary Restenosis Drug-Eluting Stents / standards* Female Humans Hyperlipidemias Japan Kidney Failure, Chronic / complications*, therapy Male Middle Aged Recurrence Renal Dialysis Sirolimus / administration & dosage* Stents / standards* |
| Chemical | |
Reg. No./Substance:
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53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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