Document Detail


Sirolimus-eluting stent in the prevention of restenosis in small coronary arteries
MedLine Citation:
PMID:  20582885     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Angioplasty of coronary arteries with a small diameter (commonly defined as diameter inferior than 2.75 mm) is associated with a high rate of restenosis and revascularization. Since the use of Drug Eluting Stents (DES) and considering their good results on simple lesions compared to other techniques (balloon dilation and bare metal stents), many studies have also demonstrated the superiority of DES in reducing restenosis and revascularization of complex lesions in particular lesions on coronary arteries with small diameter. AIM: Assessment of this revascularization procedure. METHODS: Our study is a prospective one carried on between june 2002 and august 2006, involving a cohort of 299 patients. Patients are divided into 2 groups: group I: 175 patients with 220 lesions on coronary arteries with small diameter treated by 233 sirolimus DES (Cypher) and group II: 124 patients treated by 136 angioplasty of coronary arteries with diameter superior than 2.75 mm using 179 DES. RESULTS: During hospitalisation, there was no significant difference in MACE between the 2 groups. Nevertheless, 2 patients among the first group had no angioplasty because of unsuccessful progression of the balloon through the lesion and the absence of atherectomy in our center. All patients having acute thrombosis during hospitalization and presenting with ST elevated acute coronary syndrome had successful urgent revascularization with TIMI 3 flow. The mid-term follow-up (12 months) concerned 157/174 patients in group I and 113/123 patients in group II. We observed a higher mortality and non fatal myocardial infarction in group I without statistically significant difference. CONCLUSION: despite the complexity of the lesions on coronary arteries with small diameter and despite the association with several risk factors in particular diabetes, the use of DES reduces the MACE specially secondary revascularisations thus improving early and midterm prognosis.
Authors:
Dhaker Lahidheb; Hedi Mhenni; Nadia Barakett; Othman Salah; Thouraya Filali; Abdedayem Haggui; Imen Saaidi; Nadhem Hajlaoui; Wafa Fehri; Habib Haouala
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Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  La Tunisie médicale     Volume:  88     ISSN:  0041-4131     ISO Abbreviation:  Tunis Med     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413766     Medline TA:  Tunis Med     Country:  Tunisia    
Other Details:
Languages:  fre     Pagination:  486-91     Citation Subset:  IM    
Affiliation:
Service de Cardiologie, Hôpital Militaire de Tunis.
Vernacular Title:
Le Stent A Elution De Sirolimus Dans La Prevention De La Restenose Des Arteres Coronaires De Petit Calibre.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Coronary Restenosis / prevention & control*
Drug-Eluting Stents*
Female
Humans
Male
Middle Aged
Prospective Studies
Sirolimus / administration & dosage*
Chemical
Reg. No./Substance:
53123-88-9/Sirolimus

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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