| Sirolimus for below the knee lesions: mid-term results of SiroBTK study. | |
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MedLine Citation:
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PMID: 17039538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To assess the safety and efficacy of sirolimus-eluting stents (SESs) in the treatment of severe intermittent claudication and critical limb ischaemia with "below-the-knee" lesions, unsuitable for surgery. BACKGROUND: Limited published evidence suggests that drug-eluting stents may offer significant improvements in the treatment of infrapopliteal lesions. METHODS: Thirty consecutive patients with either severe intermittent claudication or critical limb ischemia (CLI), category 3-6 of Rutherford classification, and multivessel disease of infrapopliteal arteries (> or = 2 vessels) were treated with SES. Sixty-two arteries were treated with 106 SES. Mean age was 73.9 years, 77% of patients were male and 36% diabetic. The primary endpoint was clinical improvement and healing of ulcers at short term (1 month) and mid term (7.7 months). The secondary endpoint was primary vessel patency rate (angiographic or duplex assessment). All patients received clopidogrel (75 mg daily) or ticlopidine (150 mg daily) for 2 months or longer. RESULTS: Angiographic and procedural success was achieved in all patients. At 7 months (7.7 +/- 5.8), it was necessary to amputate 1 toe in one patient and 1 mid-foot in another. Limb salvage was obtained in 100% of patients. Other events were: two cardiac deaths unrelated to CLI, one stroke with hemiparesia, one initial reperfusion syndrome, one contralateral CLI, and three recurrent homolateral claudication cases. All surviving patients had a mid-term clinical improvement with 97% of primary patency (56 patent arteries on 58 arteries). CONCLUSION: Treatment of "below-the-knee" lesions with SES may provide an alternative treatment for patients with CLI. |
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Authors:
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Philippe Commeau; Paul Barragan; Pierre O Roquebert |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 68 ISSN: 1522-1946 ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-10-31 Completed Date: 2007-06-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 793-8 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Département de Cardiologie et Radiologie Vasculaire Interventionelles, Polyclinique Les Fleurs, 83190 Ollioules, France. p.commeau@wanadoo.fr |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Vessel Prosthesis Implantation Cardiovascular Agents / therapeutic use* Coated Materials, Biocompatible / therapeutic use Equipment Safety Female Follow-Up Studies Humans Intermittent Claudication / drug therapy, physiopathology, surgery, therapy* Ischemia / drug therapy, physiopathology, surgery, therapy* Kaplan-Meiers Estimate Leg / blood supply*, surgery Male Middle Aged Peripheral Vascular Diseases / drug therapy, physiopathology, surgery, therapy* Platelet Aggregation Inhibitors / therapeutic use Popliteal Artery / pathology, physiopathology, surgery Prospective Studies Research Design Severity of Illness Index Sirolimus / therapeutic use* Stents* Time Factors Treatment Outcome Vascular Patency |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents; 0/Coated Materials, Biocompatible; 0/Platelet Aggregation Inhibitors; 53123-88-9/Sirolimus |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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