Document Detail


Sirenomelia of an intracytoplasmic sperm injection conceptus: a case report and review of mechanism.
MedLine Citation:
PMID:  16944978     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Postmortem dissection of the 18-week male conceptus, product of intracytoplasmic sperm injection (ICSI), demonstrated the hallmark findings of sirenomelia. The lower legs were fused and the left knee was rotated medially. Internal organs showed hypoplastic lungs, a multicystic kidney, and unilateral ureteral hypoplasia. The vitelline artery was absorbed, in a classic fashion, into the umbilical artery and communicated with the aorta at a point proximal to the iliac arteries. The tributaries distal to this point were hypoplastic. This finding is consistent with previously documented cases of sirenomelia and is thought to be the pathogenetic mechanism resulting in a vascular steal from the lower extremities. A rare finding was the presence of a penis on the dorsal side just below a perforate anus. In this case report, we discuss the pertinent clinical history and autopsy findings. A brief review of the mechanism thought to give rise to sirenomelia is provided. To our knowledge, this is the first reported case of sirenomelia in an ICSI conceptus.
Authors:
Omid Bakhtar; Kurt Benirschke; Eliezer Masliah
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society     Volume:  9     ISSN:  1093-5266     ISO Abbreviation:  Pediatr. Dev. Pathol.     Publication Date:    2006 May-Jun
Date Detail:
Created Date:  2006-09-01     Completed Date:  2006-10-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9809673     Medline TA:  Pediatr Dev Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  245-53     Citation Subset:  IM    
Affiliation:
UCSD Medical Center, Department of Pathology, San Diego, CA 92103, USA. Obakhtar@ucsd.edu
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Multiple / embryology,  pathology*,  radiography,  ultrasonography
Abortion, Induced
Aorta / abnormalities,  embryology,  pathology
Ectromelia / embryology,  pathology*,  radiography
Female
Fetal Death
Humans
Karyotyping
Male
Models, Anatomic
Pregnancy
Pregnancy Trimester, Second
Sperm Injections, Intracytoplasmic / methods*
Umbilical Arteries / abnormalities,  embryology,  pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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