| Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. | |
| | |
MedLine Citation:
|
PMID: 17581878 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Yeast cytokinesis entails a rejuvenation process by which the aged mother cell generates daughter cells enjoying full replicative potential. Here we show that this process includes a precipitous reduction in the levels of reactive oxygen species in the progeny immediately after completion of cytokinesis. The reduction in hydrogen peroxide is the result of a Sir2p and actin cytoskeleton-dependent segregation of the cytosolic catalase Ctt1p such that the daughter cell receives a higher load of undamaged and active Ctt1p than the progenitor cell. Such spatial quality control provides the daughter cells with a superior capacity to combat external oxidative stress and delays self-inflicted oxidative damage to their cellular proteins. |
| | |
Authors:
|
Nika Erjavec; Thomas Nyström |
Related Documents
:
|
16377848 - Reactive oxygen species, cell growth, and taxol production of taxus cuspidata cells imm... 17277908 - Inhibition of cyanide-insensitive respiration in klebsiella oxytoca sysu-011 by 8-hydro... 3759558 - Potentiation of ccnu toxicity by af-2 in v79 spheroids: implications for mechanisms of ... 10450068 - Effects of ambroxol on spontaneous or stimulated generation of reactive oxygen species ... 6334308 - Colony-stimulating factor (csf) controls proliferation of csf-dependent cells by acting... 6825908 - Changes in glycosidase activities in lectin resistant myogenesis-defective myoblast cel... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2007-06-20 |
Journal Detail:
|
Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 104 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-06-28 Completed Date: 2008-01-15 Revised Date: 2009-11-19 |
Medline Journal Info:
|
Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
|
Languages: eng Pagination: 10877-81 Citation Subset: IM |
Affiliation:
|
Department of Cell and Molecular Biology-Microbiology, Göteborg University, Medicinaregatan 9C, 413 90 Göteborg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Catalase
/
metabolism* Cytokinesis Cytoskeleton Histone Deacetylases / metabolism Hydrogen Peroxide Oxidative Stress Reactive Oxygen Species / metabolism* Saccharomyces cerevisiae / cytology*, metabolism* Saccharomyces cerevisiae Proteins / metabolism Silent Information Regulator Proteins, Saccharomyces cerevisiae / metabolism* Sirtuin 2 Sirtuins / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Reactive Oxygen Species; 0/Saccharomyces cerevisiae Proteins; 0/Silent Information Regulator Proteins, Saccharomyces cerevisiae; 7722-84-1/Hydrogen Peroxide; EC 1.11.1.6/Catalase; EC 3.5.1.-/SIR2 protein, S cerevisiae; EC 3.5.1.-/Sirtuin 2; EC 3.5.1.-/Sirtuins; EC 3.5.1.98/Histone Deacetylases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reorientional dynamics of water molecules in anionic hydration shells.
Next Document: Chronic exposure to paclitaxel diminishes phosphoinositide signaling by calpain-mediated neuronal ca...