Document Detail

Sinus node function and protamine sulfate.
MedLine Citation:
PMID:  2520639     Owner:  NLM     Status:  MEDLINE    
This report analyzes the effects of protamine sulfate (PS) on the heart rate and sinoatrial node function in dogs anesthetized with diazepam, fentanyl, and pancuronium bromide, and subjected to different modalities of extracorporeal circulation (ECC). All groups were given 3 mg/kg of heparin sodium and 5 mg/kg of PS. The sinus node function was evaluated by means of sinoatrial conduction time (SACT), absolute sinus node recovery time (SNRTa), and corrected sinus node recovery time (SNRTc). The spontaneous heart rate (HR) of the animals was also analyzed. Under the experimental conditions established in this study, the intravenous administration of a bolus of PS produced a decrease in the HR in all the groups, regardless of the type of ECC used. The modifications in the conduction and recovery times of the sinus node by PS did not correlate with those of the heart rate; the sinoatrial conduction time increased in groups subjected to ECC, while the absolute and corrected recovery times of the sinus node were prolonged only in the group that underwent rapid rewarming.
J Alvarez; L Alvarez; C Escudero; J L Castillo Olivares
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiothoracic anesthesia     Volume:  3     ISSN:  0888-6296     ISO Abbreviation:  J Cardiothorac Anesth     Publication Date:  1989 Feb 
Date Detail:
Created Date:  1992-06-15     Completed Date:  1992-06-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8709732     Medline TA:  J Cardiothorac Anesth     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  44-51     Citation Subset:  IM    
Service of Anesthesia, Hospital Santa Cruz y San Pablo, Barcelona, Spain.
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MeSH Terms
Aorta / surgery
Blood Pressure / drug effects
Bundle of His / drug effects,  physiology
Cardioplegic Solutions / administration & dosage
Central Venous Pressure / drug effects
Extracorporeal Circulation*
Heart Rate / drug effects*,  physiology
Heparin / therapeutic use
Hypothermia, Induced
Myocardial Contraction / drug effects,  physiology
Protamines / pharmacology*
Pulmonary Artery
Pulmonary Wedge Pressure / drug effects
Reaction Time / drug effects
Sinoatrial Node / drug effects*,  physiology
Time Factors
Reg. No./Substance:
0/Cardioplegic Solutions; 0/Protamines; 9005-49-6/Heparin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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