Document Detail


Sinus histiocytosis with massive lymphadenopathy--a review of seven cases.
MedLine Citation:
PMID:  17183839     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Sinus histiocytosis with massive lymphadenopathy (SHML) also called as Rosai Dorfman disease is a rare histiocytic proliferative disorder of unknown etiology. Histological features currently define it. Persistent painless lymphadenopathy due to expansion of sinuses infiltrated with benign histiocytes and plasma cells and emperipolesis are the characteristic features of SHML. Our study includes seven cases (5 nodal and 2 extranodal) of SHML over a 5-year period whose slides and blocks were reviewed. IHC was performed on the main lesion, from a panel of S100, CD68, LCA, CD20, CD3, CD30, CD43, bcl2, cytokeratin and epithelial membrane antigen. In our series we have work up available in 7 cases out of which a detailed follow-up is available in 5 patients. Out of these 5 patients, 4 have a stable disease, while one developed histiocytic sarcoma after a gap of four years.
Authors:
Atin Agarwal; Suniti Pathak; Sumeet Gujral
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Indian journal of pathology & microbiology     Volume:  49     ISSN:  0377-4929     ISO Abbreviation:  Indian J Pathol Microbiol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-12-22     Completed Date:  2007-01-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7605904     Medline TA:  Indian J Pathol Microbiol     Country:  India    
Other Details:
Languages:  eng     Pagination:  509-15     Citation Subset:  IM    
Affiliation:
Department of Pathology, Tata Memorial Hospital, Parel, Mumbai.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Female
Histiocytes / pathology
Histiocytosis, Sinus / pathology*
Humans
Lymph Nodes / pathology*
Lymphatic Diseases / pathology*
Male
Middle Aged
Phagocytosis

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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