Document Detail

Sinus aspirates in chronic rhinosinusitis: fungal colonization of paranasal sinuses, evaluation of ICAM-1 and IL-8 and studying of immunological effect of long-term macrolide therapy.
MedLine Citation:
PMID:  21038022     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In patients with chronic fungal sinusitis, concentrations of interleukin-8 (IL-8), immunoglobulin E (IgE), and soluble intercellular adhesion molecule-1 (sICAM-1) were compared in paranasal sinus aspirates and serum. Furthermore, immunological effects of macrolide treatment of our patients with chronic fungal rhinosinusitis were also studied.
MATERIAL AND METHODS: In our cohort study, 108 patients with chronic rhinosinusitis undergoing sinus surgery were selected. Sinus aspirates were collected, and used for immunological assasy and cultured for fungal study. All patients were examined for the presence of characteristic allergic mucin of chronic allergic fungal rhinosinusitis and this was confirmed later by measurement of total serum IgE.
RESULTS: Our cases were classified into 3 groups: chronic rhinosinusitis with positive fungal culture and negative allergic mucin, chronic rhinosinusitis with positive fungal culture and positive allergic mucin and chronic rhinosinusitis without fungal growth. A control group was included. We found 57.4% of the patient cultures positive for fungus and 36.4% of the control subjects. Aspergillus ssp. were the most prevalent followed by Bipolaris ssp., and Curvularia. IgE levels were increased in group II compared to group I, III and IV. ICAM-1 and IL-8 levels were increased in groups I, II and III compared to the control group. Erythromycin given in group II decreased the levels of IL-8 and ICAM-1.
CONCLUSION: Aspergillus species were the most common. These results confirm the role of ICAM-1 and IL-8 in all types of rhinosinusitis. Erythromycin modulated the immune status of the patients.
Shawky Elmorsy; Mohammed M El-Naggar; Sanaa M Abdel aal; Mohammad A Abou-elela
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Rhinology     Volume:  48     ISSN:  0300-0729     ISO Abbreviation:  Rhinology     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-11-01     Completed Date:  2010-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0347242     Medline TA:  Rhinology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  312-7     Citation Subset:  IM    
Otorhinolaryngology Department, Mansoura University, Mansoura, Egypt.
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MeSH Terms
Anti-Bacterial Agents / administration & dosage
Chronic Disease
Erythromycin / administration & dosage
Immunoglobulin E / analysis
Intercellular Adhesion Molecule-1 / analysis*,  blood
Interleukin-8 / analysis*,  blood
Paranasal Sinuses / microbiology*
Rhinitis / microbiology*
Sinusitis / microbiology*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Interleukin-8; 114-07-8/Erythromycin; 126547-89-5/Intercellular Adhesion Molecule-1; 37341-29-0/Immunoglobulin E

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