| Sinulaflexiolides A-K, cembrane-type diterpenoids from the chinese soft coral Sinularia flexibilis. | |
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MedLine Citation:
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PMID: 18553926 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A-K (1-11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 microM, respectively. |
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Authors:
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Ting Wen; Yi Ding; Zhiwei Deng; Leen van Ofwegen; Peter Proksch; Wenhan Lin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-14 |
Journal Detail:
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Title: Journal of natural products Volume: 71 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-25 Completed Date: 2008-09-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1133-40 Citation Subset: IM |
Affiliation:
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State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anthozoa / chemistry Antineoplastic Agents / chemistry, isolation & purification*, pharmacology China Diterpenes / chemistry, isolation & purification*, pharmacology Drug Screening Assays, Antitumor Humans Molecular Structure |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/Diterpenes; 0/sinulaflexiolide D; 0/sinulaflexiolide E |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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