Document Detail


Sinulaflexiolides A-K, cembrane-type diterpenoids from the chinese soft coral Sinularia flexibilis.
MedLine Citation:
PMID:  18553926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A bioassay-guided fractionation and chemical examination of the soft coral Sinularia flexibilis resulted in the isolation and characterization of sinulaflexiolides A-K (1-11), along with sinulariolone (12), 5-dehydrosinularolide (13), capillolide (14), sinulariolide (15), 5,8-epoxy-9-acetoxysinulariolide (16), flexibilide (17), dihydroflexibilide (18), and the enantiomer of 14-deoxycrassin (19). Their structures were determined on the basis of extensive spectroscopic (IR, MS, 2D NMR) data analysis and by comparison with spectroscopic data reported in the literature. Sinulaflexiolides D and E showed selective inhibitory activity against the gastric gland carcinoma cell line BGC-823 at 8.5 and 0.12 microM, respectively.
Authors:
Ting Wen; Yi Ding; Zhiwei Deng; Leen van Ofwegen; Peter Proksch; Wenhan Lin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-14
Journal Detail:
Title:  Journal of natural products     Volume:  71     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-25     Completed Date:  2008-09-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1133-40     Citation Subset:  IM    
Affiliation:
State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100083, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anthozoa / chemistry
Antineoplastic Agents / chemistry,  isolation & purification*,  pharmacology
China
Diterpenes / chemistry,  isolation & purification*,  pharmacology
Drug Screening Assays, Antitumor
Humans
Molecular Structure
Chemical
Reg. No./Substance:
0/Antineoplastic Agents; 0/Diterpenes; 0/sinulaflexiolide D; 0/sinulaflexiolide E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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