Document Detail

[Sinonasal tract malignancies : A 14-year single institution experience].
MedLine Citation:
PMID:  23202858     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: With a worldwide annual incident rate of 1/200,000 sinonasal tract malignancies are a relatively rare disease.
MATERIAL AND METHODS: All patients with sinonasal malignancies (n = 177) treated between 1996 and 2010 at the Department of Head and Neck Surgery, University of Bonn, Germany were analyzed retrospectively. Data on age, gender and incidence were available for all patients but other demographic data, treatment regimes and outcome were only analyzed for carcinomas.
RESULTS: Carcinomas were the most frequent histological diagnosis (58%). Unspecific sinonasal symptoms lasted on average for 4.7 ± 5 months before primary diagnosis. Interestingly, 64% of patients with sinonasal carcinoma presented with locally advanced disease (T3-4) but only 15% displayed corresponding regional lymph node metastases. The overall 3-year survival rate was 61%. Patients solely needing surgical treatment displayed a better survival rate than patients receiving combined surgery and adjuvant treatment or definitive radio(chemo)therapy. Multivariate analysis revealed a T-stage classification as the only independent prognostic factor for 3-year survival.
CONCLUSIONS: Due to unspecific symptoms most sinonasal malignancies are diagnosed at an advanced stage of the disease and despite multimodal therapies these tumors still have an unfavorable prognosis.
A Schröck; F Göke; T van Bremen; R Kirsten; M Jakob; T Ehrenberg; M Kühnemund; A Gerstner; K W G Eichhorn
Publication Detail:
Type:  English Abstract; Journal Article    
Journal Detail:
Title:  HNO     Volume:  60     ISSN:  1433-0458     ISO Abbreviation:  HNO     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985099R     Medline TA:  HNO     Country:  Germany    
Other Details:
Languages:  ger     Pagination:  1041-6     Citation Subset:  IM    
Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde/-Chirurgie, Universitätsklinikum Bonn, Sigmund-Freud-Str. 25, 53105, Bonn, Deutschland,
Vernacular Title:
Maligne Erkrankungen des Sinunasaltrakts : Eine monoinstitutionelle Erfahrung von 1996 bis 2010.
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