Document Detail


Singular spectrum analysis applied to ultrasonic detection and imaging of brachytherapy seeds.
MedLine Citation:
PMID:  17407916     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ultrasound-guided brachytherapy using titanium-shelled radioactive seeds is a popular, effective means of treating prostate cancer. Unfortunately, implantation using needles inserted transperitoneally causes gland movement and distortion, which often results in seed misplacement and dosimetry errors. If actual seed locations could be determined in the operating room, then corrections to dosimetry errors could be made immediately. However, seed specularity, shadowing, and tissue clutter make imaging seeds difficult using conventional ultrasound. Singular spectrum analysis (SSA) shows promise for reliably imaging radioactive seeds implanted in the prostate and enabling additional corrective implantations to be made in the operating room. SSA utilizes eigenvalues derived from the diagonalized correlation matrix of envelope-detected radio-frequency echo signals to yield a P value indicative of the likelihood of a seed-specific repetitive signal. We demonstrated the potential of SSA for seed detection and imaging and illustrated the trade-off considerations for optimization of SSA in clinical applications using simulations assessing performance as a function of different levels of noise and the presence of repetitive signals with various repetition periods; experiments in an ideal scattering environment; and experiments using seeds implanted in beef.
Authors:
Jonathan Mamou; Ernest J Feleppa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The Journal of the Acoustical Society of America     Volume:  121     ISSN:  0001-4966     ISO Abbreviation:  J. Acoust. Soc. Am.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-05     Completed Date:  2007-05-01     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  7503051     Medline TA:  J Acoust Soc Am     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1790-801     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Brachytherapy / instrumentation*
Humans
Male
Models, Biological
Prostatic Neoplasms / therapy*
Spectrum Analysis
Ultrasonics*
Grant Support
ID/Acronym/Agency:
CA098465/CA/NCI NIH HHS; R01 CA098465/CA/NCI NIH HHS; R01 CA098465-01A2/CA/NCI NIH HHS; R01 CA098465-02/CA/NCI NIH HHS; R01 CA098465-03/CA/NCI NIH HHS; R01 CA098465-04/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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