| Singlet oxygen quenching activity of human serum. | |
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MedLine Citation:
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PMID: 15720827 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Singlet oxygen is regarded as contributing to the pathogenesis of various diseases including light-induced skin disorders and inflammatory response. In this study, the correlation between singlet oxygen quenching activity (SOQA) of human serum and blood biochemistry or life-style was evaluated. Healthy volunteers were recruited and carried out a measurement of SOQA by using electron paramagnetic resonance (EPR) and a questionnaire survey about a smoking. It was demonstrated that major quenchers of singlet oxygen in serum are proteins, and small molecular anti-oxidants relatively play a minor role. SOQA of whole sera showed no correlation with protein concentration, but positively correlated with SOQA of small molecular fraction. In vitro studies demonstrated that the decrease of sulfhydryl groups by NO or superoxide significantly attenuated SOQA of albumin. Together, these results may imply that the underlying oxidative condition in each individual influences both small molecular antioxidant states and the sulfhydryl content of serum proteins. SOQA of sera from women with a smoking history was significantly lower compared to non-smoking women, suggesting that the smoking habit impaired the defense mechanism against singlet oxygen. |
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Authors:
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Tatsuya Kon; Toru Tanigawa; Kohsuke Hayamizu; Manzhen Shen; Tomoko Tsuji; Yuji Naito; Toshikazu Yoshikawa |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Redox report : communications in free radical research Volume: 9 ISSN: 1351-0002 ISO Abbreviation: Redox Rep. Publication Date: 2004 |
Date Detail:
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Created Date: 2005-02-21 Completed Date: 2005-07-19 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9511366 Medline TA: Redox Rep Country: England |
Other Details:
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Languages: eng Pagination: 325-30 Citation Subset: IM |
Affiliation:
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Central Research Laboratory, FANCL Corporation, Kanagawa, Yokohama, Japan. kon@fancl.co.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Proteins / analysis, physiology* Electron Spin Resonance Spectroscopy Female Humans Life Style Male Middle Aged Oxidation-Reduction Oxidative Stress Serum* Serum Albumin / analysis Singlet Oxygen / blood*, physiology* Smoking / blood Sulfhydryl Compounds / blood gamma-Globulins / analysis |
| Chemical | |
Reg. No./Substance:
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0/Blood Proteins; 0/Serum Albumin; 0/Sulfhydryl Compounds; 0/gamma-Globulins; 17778-80-2/Singlet Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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