| Single-walled carbon nanotube as an effective quencher. | |
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MedLine Citation:
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PMID: 19898820 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the past few years, single-walled carbon nanotubes (SWNTs) have been the focus of intense research motivated by their unique physical and chemical properties. This review specifically summarizes recent progress in the development of fluorescence biosensors that integrate the quenching property of SWNTs and the recognition property of functional nucleic acids. SWNTs are substantially different from organic quenchers, showing superior quenching efficiency for a variety of fluorophores, with low background and high signal-to-noise ratio, as well as other advantages derived from the nanomaterial itself. As the second key component of biosensors, functional nucleic acids can bind to either their complementary DNA or a target molecule with the ability to recognize a broad range of targets from metal ions to organic molecules, proteins, and even live cells. By taking advantage of the strengths and properties of both SWNTs and nucleic acid based aptamers, a series of fluorescence biosensors have been designed and fabricated for the detection of a broad range of analytes with high selectivity and sensitivity. |
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Authors:
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Zhi Zhu; Ronghua Yang; Mingxu You; Xiaoling Zhang; Yanrong Wu; Weihong Tan |
Publication Detail:
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Type: Journal Article; Review Date: 2009-11-08 |
Journal Detail:
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Title: Analytical and bioanalytical chemistry Volume: 396 ISSN: 1618-2650 ISO Abbreviation: Anal Bioanal Chem Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-21 Completed Date: 2010-03-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101134327 Medline TA: Anal Bioanal Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 73-83 Citation Subset: IM |
Affiliation:
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Center for Research at Bio/nano Interface, Department of Chemistry, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL 32611-7200, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biosensing Techniques
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instrumentation,
trends* DNA / chemistry Fluorescent Dyes / chemistry* Hydrogen-Ion Concentration Nanotubes, Carbon / chemistry* |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes; 0/Nanotubes, Carbon; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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