| Single-voxel proton MR spectroscopy of right versus left hippocampi in PTSD. | |
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MedLine Citation:
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PMID: 12850249 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous magnetic resonance (MR) volume imaging and proton MR spectroscopy studies have suggested a reduction in the hippocampal size and/or neuronal/axonal density in posttraumatic stress disorder (PTSD). The lack of agreement on the laterality of the hippocampal dysfunction prompted this study. A total of 20 veterans (18 men and two women) and one female non-veteran participated in this study conducted in accordance with approved human study protocols. Six of the male veterans and the female non-veteran were without PTSD. Vietnam veterans formed a large subset of the study subjects. Single-voxel proton MR spectra were obtained from the hippocampal region bilaterally on a clinical MR scanner operating at 1.5 T. Analysis of the proton MR spectra showed a decrease in hippocampal NAA/creatine ratio in PTSD subjects significantly higher on the left than the right for the entire study group, as well as for the Vietnam subset. It was concluded that the hippocampal dysfunction in PTSD is lateralized with the left side being more impaired than the right. |
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Authors:
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P Mohanakrishnan Menon; Henry A Nasrallah; Judith A Lyons; Mertis F Scott; Vincent Liberto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Psychiatry research Volume: 123 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-07-09 Completed Date: 2003-11-04 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 101-8 Citation Subset: IM |
Affiliation:
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Department of Psychiatry and Human Behaviour, University of Mississippi Medical Center, Jackson, MS 39216, USA. parekkat.mohanakrishnan@med.va.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aspartic Acid / analogs & derivatives*, metabolism Cell Survival Choline / metabolism Combat Disorders / diagnosis, physiopathology* Creatine / metabolism Dominance, Cerebral / physiology Energy Metabolism / physiology* Female Hippocampus / physiopathology* Humans Image Processing, Computer-Assisted* Magnetic Resonance Imaging* Magnetic Resonance Spectroscopy* Male Middle Aged Neurons / physiology Reference Values Stress Disorders, Post-Traumatic / diagnosis, physiopathology* Veterans / psychology* |
| Chemical | |
Reg. No./Substance:
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56-84-8/Aspartic Acid; 57-00-1/Creatine; 62-49-7/Choline; 997-55-7/N-acetylaspartate |
| Comments/Corrections | |
Erratum In:
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Psychiatry Res. 2004 Apr 30;130(3):313 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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