Document Detail


Single v. multiple measures of skin carotenoids by resonance Raman spectroscopy as a biomarker of usual carotenoid status.
MedLine Citation:
PMID:  23351238     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Resonance Raman spectroscopy (RRS) is a non-invasive method of assessing carotenoid status in the skin, which has been suggested as an objective indicator of fruit/vegetable intake. The present study assessed agreement and identified predictors of single v. multiple RRS measures of skin carotenoid status. A total of seventy-four participants had their skin carotenoid status measured in the palm of the hand by RRS at six time points over 6 months. Questionnaires were administered to collect information on demographic, lifestyle and dietary data. Mean age of the participants was 36.6 years, 62.2% were female, 83.8% Caucasian and 85.1% were non-smoking at baseline. There was a good agreement between a single measure of skin carotenoids by RRS and multiple measures (weighted κ = 0.80; 95% CI 0.72, 0.88). The same variables were significantly associated with carotenoid status based on single or multiple measures, including a positive association with intake of total carotenoids (P< 0.01) and an inverse association with season of measurement (P≤ 0.05). The exception was recent sun exposure, which emerged as a significant predictor of lower carotenoid status only when using multiple RRS measures (P≤ 0.01). A single RRS measure was reasonably accurate at classifying usual skin carotenoid status. Researchers using RRS may want to take into account other factors that are associated with the biomarker, including season of measurement and recent sun exposure.
Authors:
Stephanie Scarmo; Brenda Cartmel; Haiqun Lin; David J Leffell; Igor V Ermakov; Werner Gellermann; Paul S Bernstein; Susan T Mayne
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-28
Journal Detail:
Title:  The British journal of nutrition     Volume:  110     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2013 Sep 
Date Detail:
Created Date:  2013-08-21     Completed Date:  2013-11-18     Revised Date:  2014-07-25    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  911-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / analysis
Carotenoids / analysis*
Diet
Female
Fruit
Humans
Male
Middle Aged
Seasons
Skin / chemistry*
Skin Pigmentation
Smoking / metabolism
Spectrum Analysis, Raman / methods*
Vegetables
Young Adult
Grant Support
ID/Acronym/Agency:
A05202//PHS HHS; M03A00158//PHS HHS; P30 EY014800/EY/NEI NIH HHS; R01 CA096838/CA/NCI NIH HHS; R01 CA096838/CA/NCI NIH HHS; R01 EY011600/EY/NEI NIH HHS; R01 EY11600/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 36-88-4/Carotenoids
Comments/Corrections

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