Document Detail


Single-unit responses to cholinergic agents in the rat inferior colliculus.
MedLine Citation:
PMID:  6309726     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Single units were recorded from the inferior colliculi of adult male rats anesthetized with urethane. Units were driven with tonal stimuli, and changes in unit responses to the tones were monitored during iontophoretic application of cholinergic drugs. The cholinergic agonists acetylcholine and carbamylcholine potentiated responses in about 50% and suppressed responses in about 35% of units tested. Cholinergic antagonists typically produced effects when delivered alone. Both d-tubocurarine and atropine methyl nitrate excited over 80% of units tested, while mecamylamine and scopolamine inhibited the majority of tested units. Dihydro-beta-erythroidine was generally ineffective. Alpha-bungarotoxin was generally ineffective when delivered alone, but blocked agonist effects. Post-stimulus time histogram (PSTH) patterns, response-intensity functions and response areas were examined for changes during drug delivery. Cholinergic agents did not differentially affect either time periods within the PSTH or frequency bands of response areas, but were especially effective for those intensities producing larger response rates. Taken together with evidence from biochemical studies, our results suggest the presence of a functional cholinergic input into the inferior colliculus which acts to modulate acoustic processing.
Authors:
G R Farley; B J Morley; E Javel; M P Gorga
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Hearing research     Volume:  11     ISSN:  0378-5955     ISO Abbreviation:  Hear. Res.     Publication Date:  1983 Jul 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7900445     Medline TA:  Hear Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  73-91     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Auditory Perception / drug effects
Evoked Potentials, Auditory / drug effects
Inferior Colliculi / drug effects*
Male
Muridae
Parasympathomimetics / pharmacology*
Receptors, Cholinergic / drug effects*
Synaptic Transmission / drug effects
Grant Support
ID/Acronym/Agency:
NS06337/NS/NINDS NIH HHS; NS07147/NS/NINDS NIH HHS; NS14880/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Parasympathomimetics; 0/Receptors, Cholinergic

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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