Document Detail

Single-trials analyses demonstrate that increases in clock speed contribute to the methamphetamine-induced horizontal shifts in peak-interval timing functions.
MedLine Citation:
PMID:  16937099     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Drugs that increase dopamine (DA) transmission have been shown to produce an overestimation of time in duration production procedures as exhibited by horizontal leftward shifts of the psychophysical functions. However, the generality of these results has been inconsistent in the literature. MATERIALS AND METHODS: The present report evaluates the effects of five doses of methamphetamine (MAP) (0.5-1.5 mg/kg, i.p.) on two duration production procedures, the single duration peak-interval (PI) procedure and the multiduration tri-peak procedure in rats. RESULTS: We replicated and extended prior results by showing a dose-dependent proportional overestimation of time that was equivalent on both procedures (i.e., subjects behaved as though they expected reinforcement to be available earlier in real time). Single-trials analyses demonstrated that the reduction in peak rate that is often observed after MAP administration is due to an increase in the proportion of trials in which responding occurred at very low rates and without temporal control. However, these low-rate trials were not the source of the leftward shift in the temporal estimates. Rather, we found that the leftward shift of the PI functions was due to proportional changes in the placement of temporally controlled high-rate responding, which is consistent with a DA-mediated alteration in clock speed.
Matthew S Matell; Melissa Bateson; Warren H Meck
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Publication Detail:
Type:  Journal Article     Date:  2006-08-26
Journal Detail:
Title:  Psychopharmacology     Volume:  188     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-08     Completed Date:  2007-01-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  201-12     Citation Subset:  IM    
Department of Psychology, Villanova University, 800 Lancaster Avenue, Villanova, PA, 19085, USA.
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MeSH Terms
Behavior, Animal / drug effects*
Central Nervous System Stimulants / pharmacology*
Data Interpretation, Statistical
Dose-Response Relationship, Drug
Methamphetamine / pharmacology*
Rats, Sprague-Dawley
Reinforcement Schedule*
Time Perception / drug effects*
Reg. No./Substance:
0/Central Nervous System Stimulants; 537-46-2/Methamphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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